Journal Article

Improving gastrointestinal quality of life: romidepsin to tucidinostat in a case of angioimmunoblastic T cell lymphoma

Terasaki, Yukie, Saito, Akio, Isoda, Atsushi, Kanaya, Shuhei

2024

Overview

Relapsed/refractory (R/R) peripheral T cell lymphoma (PTCL) has a poor prognosis, with limited treatment options and generally no durable response. However, long-term remission with the histone deacetylase (HDAC) inhibitor romidepsin has been reported, especially in angioimmunoblastic T cell lymphoma (AITL). Recently, tucidinostat, a novel oral HDAC inhibitor that selectively inhibits class I and class IIb HDACs, was approved for R/R PTCL in China and Japan. We present the case of a patient with AITL whose gastrointestinal symptoms and health-related quality of life improved after switching from romidepsin to tucidinostat as maintenance therapy. Romidepsin and tucidinostat appear to have different safety profiles; non-haematological toxicities such as nausea, vomiting, constipation, anorexia and fatigue may be reported less frequently with tucidinostat than with romidepsin. This case suggests that switching to tucidinostat therapy may be a viable option for patients with PTCL suffering from severe gastrointestinal adverse events with romidepsin.

• Publisher: BMJ Publishing Group Ltd,BMJ Publishing Group LTD
• Subject: Aminopyridines / Anorexia / Benzamides / Bone marrow / Case reports / Case Reports: Adverse drug reactions and complications / Chemotherapy / Clinical trials / Constipation / Depsipeptides - adverse effects / Drug dosages / Drug withdrawal / FDA approval / Health care / Hematology / Humans / Lymphocytes / Lymphoma / Lymphoma, T-Cell, Peripheral / Medical prognosis / Nausea / Neoplasm Recurrence, Local / Neutropenia / Patients / Quality of Life / Questionnaires / Remission (Medicine) / Thrombocytopenia / Toxicity / Unwanted effects / adverse reactions / Vomiting