Asset Details
Do you wish to reserve the book?
A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study
Do you wish to request the book?
A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study
2023
Overview
AbstractObjectiveTo investigate the association of genetically proxied (using a surrogate biomarker) inhibition of phosphodiesterase 5 (PDE5), an established drug target for erectile dysfunction, with fertility, sexual behaviour, and subjective wellbeing.DesignTwo sample cis-mendelian randomisation study.SettingSummary data on genetic associations obtained from the International Consortium for Blood Pressure and UK Biobank.ParticipantsIndividuals of European ancestry from the International Consortium for Blood Pressure (n=757 601) for estimating PDE5 inhibition (using the surrogate biomarker of diastolic blood pressure reduction), and UK Biobank (n=211 840) for estimating the fertility, sexual behaviour, and subjective wellbeing outcomes in male participants.InterventionGenetically proxied PDE5 inhibition.Main outcome measuresNumber of children fathered, number of sexual partners, probability of never having had sexual intercourse, and subjective wellbeing.ResultsGenetically proxied PDE5 inhibition was associated with male participants having 0.28 (95% confidence interval 0.16 to 0.39) more children (false discovery rate corrected P<0.001). This association was not identified in female participants. No evidence was found of an association between genetically proxied PDE5 inhibition and number of sexual partners, probability of never having had sexual intercourse, or self-reported wellbeing in male participants.ConclusionsThe findings of this study provide genetic support for PDE5 inhibition potentially increasing the number of children fathered by male individuals. Absence of this association in female participants supports increased propensity for sustained and robust penile erections as a potential underlying mechanism. Further studies are required to confirm this, however, and these findings should not promote indiscriminate use of PDE5 inhibitors, which can also have harmful adverse effects.
Publisher
British Medical Journal Publishing Group,BMJ Publishing Group LTD
Subject
