Journal Article

Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial

Wang, Shuo, Chen, Xin-Zhong, Xu, Li-Li, Chen, Liang, Jiang, Ming, Guo, Hui-Ning, Li, Ai-Yuan, Yang, Tian, Wang, Dong-Xin, Sessler, Daniel I, Deng, Chun-Mei, Sun, Xin-Yu, Zeng, Yuan, Feng, Shan-Wu, Hu, Han, Han, Tao, Yuan, Hong-Mei, Zhang, Hui-Ying

2024

Overview

AbstractObjectiveTo determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression.DesignRandomised, double blind, placebo controlled trial with two parallel arms.SettingFive tertiary care hospitals in China, 19 June 2020 to 3 August 2022.Participants364 mothers aged ≥18 years who had at least mild prenatal depression as indicated by Edinburgh postnatal depression scale scores of ≥10 (range 0-30, with higher scores indicating worse depression) and who were admitted to hospital for delivery.InterventionsParticipants were randomly assigned 1:1 to receive either 0.2 mg/kg esketamine or placebo infused intravenously over 40 minutes after childbirth once the umbilical cord had been clamped.Main outcome measuresThe primary outcome was prevalence of a major depressive episode at 42 days post partum, diagnosed using the mini-international neuropsychiatric interview. Secondary outcomes included the Edinburgh postnatal depression scale score at seven and 42 days post partum and the 17 item Hamilton depression rating scale score at 42 days post partum (range 0-52, with higher scores indicating worse depression). Adverse events were monitored until 24 hours after childbirth.ResultsA total of 364 mothers (mean age 31.8 (standard deviation 4.1) years) were enrolled and randomised. At 42 days post partum, a major depressive episode was observed in 6.7% (12/180) of participants in the esketamine group compared with 25.4% (46/181) in the placebo group (relative risk 0.26, 95% confidence interval (CI) 0.14 to 0.48; P<0.001). Edinburgh postnatal depression scale scores were lower in the esketamine group at seven days (median difference −3, 95% CI −4 to −2; P<0.001) and 42 days (−3, −4 to −2; P<0.001). Hamilton depression rating scale scores at 42 days post partum were also lower in the esketamine group (−4, −6 to −3; P<0.001). The overall incidence of neuropsychiatric adverse events was higher in the esketamine group (45.1% (82/182) v 22.0% (40/182); P<0.001); however, symptoms lasted less than a day and none required drug treatment.ConclusionsFor mothers with prenatal depression, a single low dose of esketamine after childbirth decreases major depressive episodes at 42 days post partum by about three quarters. Neuropsychiatric symptoms were more frequent but transient and did not require drug intervention.Trial registrationClinicalTrials.gov NCT04414943.

• Publisher: British Medical Journal Publishing Group,BMJ Publishing Group LTD
• Subject: Adult / Adverse events / Anesthesia / Antidepressive Agents - administration & dosage / Antidepressive Agents - adverse effects / Antidepressive Agents - therapeutic use / Anxiety / Blood pressure / Catheters / Cesarean section / Childbirth & labor / China - epidemiology / Clinical trials / Data collection / Depression, Postpartum - drug therapy / Depression, Postpartum - prevention & control / Depressive Disorder, Major - drug therapy / Depressive Disorder, Major - prevention & control / Double-Blind Method / Drug dosages / Emotional disorders / Epidural / FDA approval / Female / Heart rate / Humans / Ketamine / Ketamine - administration & dosage / Ketamine - adverse effects / Mood disorders / Mothers / Mothers - psychology / Nurses / Placebos / Postpartum depression / Pregnancy / Pregnancy Complications - drug therapy / Pregnancy Complications - psychology / Prenatal depression / Psychiatric Status Rating Scales / Psychiatrists / Social support / Treatment Outcome / Umbilical cord