Journal Article

Artificial intelligence and colonoscopy experience: lessons from two randomised trials

Maselli, Roberta, Di Paolo, Dhanai, De Gottardi, Andrea, Sharma, Prateek, Antonelli, Giulio, Radaelli, Franco, Rösch, Thomas, Fugazza, Alessandro, Capogreco, Antonio, Carrara, Silvia, Spadaccini, Marco, Repici, Alessandro, Spada, Cristiano, Correale, Loredana, Amato, Arnaldo, Pellegatta, Gaia, Lollo, Gianluca, Anderloni, Andrea, Rondonotti, Emanuele, Badalamenti, Matteo, Wallace, Michael B, Milluzzo, Sebastian Manuel, Savevski, Victor, Galtieri, Piera Alessia, Hassan, Cesare, Ferrara, Elisa

2022

Overview

Background and aimsArtificial intelligence has been shown to increase adenoma detection rate (ADR) as the main surrogate outcome parameter of colonoscopy quality. To which extent this effect may be related to physician experience is not known. We performed a randomised trial with colonoscopists in their qualification period (AID-2) and compared these data with a previously published randomised trial in expert endoscopists (AID-1).MethodsIn this prospective, randomised controlled non-inferiority trial (AID-2), 10 non-expert endoscopists (<2000 colonoscopies) performed screening/surveillance/diagnostic colonoscopies in consecutive 40–80 year-old subjects using high-definition colonoscopy with or without a real-time deep-learning computer-aided detection (CADe) (GI Genius, Medtronic). The primary outcome was ADR in both groups with histology of resected lesions as reference. In a post-hoc analysis, data from this randomised controlled trial (RCT) were compared with data from the previous AID-1 RCT involving six experienced endoscopists in an otherwise similar setting.ResultsIn 660 patients (62.3±10 years; men/women: 330/330) with equal distribution of study parameters, overall ADR was higher in the CADe than in the control group (53.3% vs 44.5%; relative risk (RR): 1.22; 95% CI: 1.04 to 1.40; p<0.01 for non-inferiority and p=0.02 for superiority). Similar increases were seen in adenoma numbers per colonoscopy and in small and distal lesions. No differences were observed with regards to detection of non-neoplastic lesions. When pooling these data with those from the AID-1 study, use of CADe (RR 1.29; 95% CI: 1.16 to 1.42) and colonoscopy indication, but not the level of examiner experience (RR 1.02; 95% CI: 0.89 to 1.16) were associated with ADR differences in a multivariate analysis.ConclusionsIn less experienced examiners, CADe assistance during colonoscopy increased ADR and a number of related polyp parameters as compared with the control group. Experience appears to play a minor role as determining factor for ADR.Trial registration numberNCT:04260321.

• Publisher: BMJ Publishing Group Ltd and British Society of Gastroenterology,BMJ Publishing Group LTD
• Subject: Adenoma / Adenoma - diagnosis / Adenoma - pathology / Adult / Aged / Aged, 80 and over / Artificial Intelligence / Biopsy / Clinical trials / Cognition & reasoning / Colon / Colonic Polyps - diagnosis / Colonic Polyps - pathology / Colonoscopy / Colorectal cancer / Colorectal Neoplasms - diagnosis / Colorectal Neoplasms - pathology / Early Detection of Cancer / Endoscopy / Female / Humans / Intubation / Lesions / Male / Mass Screening / Middle Aged / Multivariate analysis / Patients / Polyps / screening / Skills / Tumors