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Anaphylactic shock and cardiac arrest after intravenous injection of sulphur hexafluoride SonoVue
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Anaphylactic shock and cardiac arrest after intravenous injection of sulphur hexafluoride SonoVue
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Journal Article
Anaphylactic shock and cardiac arrest after intravenous injection of sulphur hexafluoride SonoVue
2024
Overview
A male patient in his early 60s was referred to the cardiology department for evaluation of a persistent apical ventricular thrombus following a myocardial infarction. Transthoracic echocardiography could not rule out the presence of an apical thrombus, leading to the intravenous administration of the contrast agent sulphur hexafluoride (SonoVue). The patient quickly exhibited signs of anaphylaxis accompanied by haemodynamic shock, resulting in cardiac arrest. He was successfully resuscitated with no significant secondary neurological impairment. According to the European Medicines Agency, anaphylactic reactions to the contrast agent sulphur hexafluoride (SonoVue) occur in approximately 1 in 10 000 cases. To our knowledge, this represents the first case of hypersensitivity to sulphur hexafluoride (SonoVue) confirmed by positive in vitro testing.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Publishing Group
Subject
/ Anaphylaxis - chemically induced
/ Cardiopulmonary resuscitation
/ Contraindications and precautions
/ Contrast Media - administration & dosage
/ Contrast Media - adverse effects
/ CPR
/ Heart Arrest - chemically induced
/ Humans
/ Injections, Intravenous - adverse effects
/ Male
/ Myocardial Infarction - chemically induced
/ Patients
/ Phospholipids - administration & dosage
/ Phospholipids - adverse effects
/ Safety
/ Sulfur
/ Sulfur Hexafluoride - administration & dosage
