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Two cases of linagliptin-associated bullous pemphigoid resulting in sepsis and endocarditis
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Two cases of linagliptin-associated bullous pemphigoid resulting in sepsis and endocarditis
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Journal Article
Two cases of linagliptin-associated bullous pemphigoid resulting in sepsis and endocarditis
2024
Overview
We describe two patients, in their 70s, each presenting to the emergency department, with 6-week histories of progressively developing pruritic bullae. Both individuals had multiple comorbidities, including type 2 diabetes—for which they took linagliptin, chronic kidney disease, hypertension and prosthetic heart valves. Owing to systemic illness and endocarditis secondary to superadded bacterial infections, they both required intensive treatment and prolonged hospital admissions.Despite the beneficial effect of linagliptin on glycaemic control and its reported cardiovascular and renal safety profiles, we add our cases as evidence of the significant risk of developing bullous pemphigoid while taking this medication. Secondary infection of bullous pemphigoid increased the risk of developing endocarditis, particularly among individuals with a medical history of valve replacement surgery. Considering this, we advocate caution when prescribing this medication.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Publishing Group
Subject
/ Case Reports: Adverse drug reactions and complications
/ Diabetes
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - drug therapy
/ Glucagon
/ Heart
/ Humans
/ Linagliptin - adverse effects
/ Pemphigoid, Bullous - chemically induced
/ Pemphigoid, Bullous - drug therapy
/ Sepsis
/ Steroids
/ Ulcers
