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Demyelinating disease simulating brain tumours: A histopathologic assessment of seven cases
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Demyelinating disease simulating brain tumours: A histopathologic assessment of seven cases
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Journal Article
Demyelinating disease simulating brain tumours: A histopathologic assessment of seven cases
2006
Overview
Background: Demyelinating diseases can present as space occupying
lesions with in the brain. It is clinically and radiologically
difficult to differentiate them from primary neoplasms.
Histopathologically they mimic astrocytic neoplasms closely and
identifying these lesions correctly has a profound impact in treatment
and prognosis of these patients. Aims and Objectives: The objective
was to determine the histopathologic features of such acute focal
demyelinating disease that clinically presented as brain tumors.
Material and Methods: Seven cases were included for the study. Detailed
histopathological examination including stains for myelin and axon were
performed. The histopathological keys in arriving at the right
diagnoses included a well demarcated lesion that contains uniform
distribution of foamy macrophages in the absence of any associated
coagulative necrosis, sheets of gemistocytic astrocytes in the white
matter that show well-formed processes, perivascular chronic
inflammatory cell infiltration and total absence of myelin with
relative preservation of axons within these areas. Conclusion: The
degree of suspicion (clinical, radiological and histopathological)
should be high to diagnose these group of lesions. The above-mentioned
diagnostic keys should help in arriving at the correct
histopathological diagnoses of such cases.
Publisher
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust,Medknow Publications and Media Pvt. Ltd,Medip Academy
