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CT coronary plaque burden in asymptomatic patients with familial hypercholesterolaemia
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CT coronary plaque burden in asymptomatic patients with familial hypercholesterolaemia
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CT coronary plaque burden in asymptomatic patients with familial hypercholesterolaemia
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Journal Article
CT coronary plaque burden in asymptomatic patients with familial hypercholesterolaemia
2011
Overview
ObjectiveTo determine the calcium score and coronary plaque burden in asymptomatic statin-treated patients with heterozygous familial hypercholesterolaemia (FH) compared with a control group of patients with low probability of coronary artery disease, having non-anginal chest pain, using CT.Design, setting and patients101 asymptomatic patients with FH (mean age 53±7 years; 62 men) and 126 patients with non-anginal chest pain (mean age 56±7 years; 80 men) underwent CT calcium scoring and CT coronary angiography. All patients with FH were treated with statins during a period of 10±8 years before CT. The coronary calcium score and plaque burden were determined and compared between the two patient groups.ResultsThe median total calcium score was significantly higher in patients with FH (Agatston score=87, IQR 5–367) than in patients with non-anginal chest pain (Agatston score=7, IQR 0–125; p<0.001). The overall coronary plaque burden was significantly higher in patients with FH (p<0.01). Male patients with FH, whose low-density lipoprotein cholesterol levels were reduced by statins below 3.0 mmol/l, had significantly less coronary calcium (p<0.01) and plaque burden (p=0.02).ConclusionThe coronary plaque burden is high in asymptomatic middle-aged patients with FH despite intense statin treatment.
Publisher
BMJ Publishing Group Ltd and British Cardiovascular Society,BMJ Publishing Group,BMJ Publishing Group LTD
Subject
/ Biological and medical sciences
/ Calcinosis - diagnostic imaging
/ Coronary Angiography - methods
/ coronary artery disease (CAD)
/ Coronary Artery Disease - diagnostic imaging
/ Coronary Artery Disease - genetics
/ Disorders of blood lipids. Hyperlipoproteinemia
/ familial hypercholesterolaemia
/ Female
/ Genetic Predisposition to Disease
/ Heart
/ Humans
/ Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
/ Hyperlipoproteinemia Type II - complications
/ Hyperlipoproteinemia Type II - drug therapy
/ Hyperlipoproteinemia Type II - genetics
/ lipids
/ Male
/ Statins
