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![Generalised muscle weakness in young adults with congenital heart disease](https://www.mbrl.ae/o/mbrl-theme/images/site-assets/generic/no-book-image.png)
Generalised muscle weakness in young adults with congenital heart disease
by
Tobler, Daniel
, Greutmann, Matthias
, Oechslin, Erwin N
, Biaggi, Patric
, Granton, John T
, Le, Thao Lan
, Silversides, Candice K
in
Adult
/ Biological and medical sciences
/ Cardiology. Vascular system
/ Cardiomyopathy
/ Cardiovascular disease
/ Case-Control Studies
/ Chi-Square Distribution
/ Congenital diseases
/ Congenital heart disease
/ Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
/ Exercise
/ Exercise Test
/ exercise testing
/ Female
/ Gender
/ Hand Strength
/ Heart
/ Heart Defects, Congenital - complications
/ Heart Defects, Congenital - physiopathology
/ Heart failure
/ Heart rate
/ Heart surgery
/ Humans
/ Lung - physiopathology
/ Lung Volume Measurements
/ Male
/ Medical prognosis
/ Medical sciences
/ Middle Aged
/ Muscle Strength
/ Muscle Weakness - diagnosis
/ Muscle Weakness - etiology
/ Muscle Weakness - physiopathology
/ Muscle, Skeletal - physiopathology
/ Musculoskeletal system
/ Ontario
/ Physical fitness
/ Pressure
/ Quality of life
/ Respiratory Mechanics
/ respiratory muscle function
/ Respiratory Muscles - physiopathology
/ skeletal muscle function
/ Speech disorders
/ Spirometry
/ Studies
/ tetralogy
/ transposition of the great arteries
/ Ventilation
/ Young Adult
/ Young adults
2011
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Generalised muscle weakness in young adults with congenital heart disease
by
Tobler, Daniel
, Greutmann, Matthias
, Oechslin, Erwin N
, Biaggi, Patric
, Granton, John T
, Le, Thao Lan
, Silversides, Candice K
in
Adult
/ Biological and medical sciences
/ Cardiology. Vascular system
/ Cardiomyopathy
/ Cardiovascular disease
/ Case-Control Studies
/ Chi-Square Distribution
/ Congenital diseases
/ Congenital heart disease
/ Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
/ Exercise
/ Exercise Test
/ exercise testing
/ Female
/ Gender
/ Hand Strength
/ Heart
/ Heart Defects, Congenital - complications
/ Heart Defects, Congenital - physiopathology
/ Heart failure
/ Heart rate
/ Heart surgery
/ Humans
/ Lung - physiopathology
/ Lung Volume Measurements
/ Male
/ Medical prognosis
/ Medical sciences
/ Middle Aged
/ Muscle Strength
/ Muscle Weakness - diagnosis
/ Muscle Weakness - etiology
/ Muscle Weakness - physiopathology
/ Muscle, Skeletal - physiopathology
/ Musculoskeletal system
/ Ontario
/ Physical fitness
/ Pressure
/ Quality of life
/ Respiratory Mechanics
/ respiratory muscle function
/ Respiratory Muscles - physiopathology
/ skeletal muscle function
/ Speech disorders
/ Spirometry
/ Studies
/ tetralogy
/ transposition of the great arteries
/ Ventilation
/ Young Adult
/ Young adults
2011
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![Generalised muscle weakness in young adults with congenital heart disease](https://www.mbrl.ae/o/mbrl-theme/images/site-assets/generic/no-book-image.png)
Generalised muscle weakness in young adults with congenital heart disease
by
Tobler, Daniel
, Greutmann, Matthias
, Oechslin, Erwin N
, Biaggi, Patric
, Granton, John T
, Le, Thao Lan
, Silversides, Candice K
in
Adult
/ Biological and medical sciences
/ Cardiology. Vascular system
/ Cardiomyopathy
/ Cardiovascular disease
/ Case-Control Studies
/ Chi-Square Distribution
/ Congenital diseases
/ Congenital heart disease
/ Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
/ Exercise
/ Exercise Test
/ exercise testing
/ Female
/ Gender
/ Hand Strength
/ Heart
/ Heart Defects, Congenital - complications
/ Heart Defects, Congenital - physiopathology
/ Heart failure
/ Heart rate
/ Heart surgery
/ Humans
/ Lung - physiopathology
/ Lung Volume Measurements
/ Male
/ Medical prognosis
/ Medical sciences
/ Middle Aged
/ Muscle Strength
/ Muscle Weakness - diagnosis
/ Muscle Weakness - etiology
/ Muscle Weakness - physiopathology
/ Muscle, Skeletal - physiopathology
/ Musculoskeletal system
/ Ontario
/ Physical fitness
/ Pressure
/ Quality of life
/ Respiratory Mechanics
/ respiratory muscle function
/ Respiratory Muscles - physiopathology
/ skeletal muscle function
/ Speech disorders
/ Spirometry
/ Studies
/ tetralogy
/ transposition of the great arteries
/ Ventilation
/ Young Adult
/ Young adults
2011
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Generalised muscle weakness in young adults with congenital heart disease
![Generalised muscle weakness in young adults with congenital heart disease](https://syndetics.com/index.aspx?isbn=/mc.gif&issn=1355-6037&client=MBRL&type=mbrl)
Journal Article
Generalised muscle weakness in young adults with congenital heart disease
2011
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Overview
BackgroundIn patients with heart failure from acquired cardiomyopathy, respiratory and skeletal muscle weakness is common and is an independent predictor for adverse events. Despite a different underlying pathology, many young adults with congenital heart disease (CHD) develop a syndrome comparable to heart failure from acquired cardiomyopathy and may be at risk for a similar skeletal muscle weakness.ObjectivesTo assess respiratory and skeletal muscle strength in adults with complex CHD.MethodsRespiratory and skeletal muscle function was assessed in 51 adults; 41 with complex CHD (16 tetralogy of Fallot, 11 univentricular anatomy with Fontan operation and 14 with subaortic right ventricles) and 10 controls. Maximal inspiratory (MIPs) and expiratory (MEPs) pressures, handgrip strength, lung volumes and aerobic capacity (peak VO2) were measured.ResultsIn patients with CHD (age 34±13 years), average% predicted MIPs, MEPs and handgrip strength were lower than in controls (77±27% vs 106±28%, 85±32% vs 116±41% and 72±15% vs 93±14%, respectively, p≤0.01). There was no significant difference in muscle weakness between CHD subgroups. In 39% of patients with CHD, the handgrip strength, and in 22%, respiratory muscle strength was <70% predicted. These patients had a significantly lower peak VO2 (50±12% vs 64±14% predicted, p=0.008).ConclusionRespiratory and skeletal muscle weakness is common in young adults with complex CHD and similar to that found in older adults with advanced heart failure from acquired heart disease.
Publisher
BMJ Publishing Group Ltd and British Cardiovascular Society,BMJ Publishing Group,BMJ Publishing Group LTD
Subject
/ Biological and medical sciences
/ Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
/ Exercise
/ Female
/ Gender
/ Heart
/ Heart Defects, Congenital - complications
/ Heart Defects, Congenital - physiopathology
/ Humans
/ Male
/ Muscle Weakness - physiopathology
/ Muscle, Skeletal - physiopathology
/ Ontario
/ Pressure
/ Respiratory Muscles - physiopathology
/ Studies
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