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Anticoagulation in patients with liver cirrhosis: complication or therapeutic opportunity?
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Anticoagulation in patients with liver cirrhosis: complication or therapeutic opportunity?
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Journal Article
Anticoagulation in patients with liver cirrhosis: complication or therapeutic opportunity?
2013
Overview
[...]cirrhosis is also a major indication for the transfusion of blood components to treat bleeding and also for prophylaxis of bleeding. 11 The most devastating haemorrhagic complication remains variceal haemorrhage. [...]survival was increased with anticoagulation. 52 Although these are important data for proof of concept, larger, multicentre pragmatic trials with sufficient power and longitudinal follow-up will be required to examine the potential role of anticoagulation either as a therapeutic modality to reduce progression of fibrosis or for prevention of decompensation in those with early cirrhosis.
Publisher
BMJ Publishing Group Ltd and British Society of Gastroenterology,BMJ Publishing Group LTD
Subject
/ Anticoagulants - adverse effects
/ Anticoagulants - therapeutic use
/ Blood Coagulation - drug effects
/ Blood Coagulation - physiology
/ Blood Coagulation Disorders - physiopathology
/ Hemorrhage - physiopathology
/ Humans
/ Liver Cirrhosis - complications
/ Liver Cirrhosis - drug therapy
/ Liver Cirrhosis - physiopathology
/ Rodents
/ Sepsis
