Journal Article

Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion Beams

Shinoda, Hiroshi, Okamoto, Hiroyuki, Matsumoto, Yoshitaka, Kase, Yuki, Furusawa, Yoshiya, Asaba, Toru, Sakama, Makoto, Kanai, Tatsuaki

2006

Overview

Kase, Y., Kanai, T., Matsumoto, Y., Furusawa, Y., Okamoto, H., Asaba, T., Sakama, M. and Shinoda, H. Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion Beams. Radiat. Res. 166, 629–638 (2006). The microdosimetric spectra for high-energy beams of photons and proton, helium, carbon, neon, silicon and iron ions (LET = 0.5–880 keV/μm) were measured with a spherical-walled tissue-equivalent proportional counter at various depths in a plastic phantom. Survival curves for human tumor cells were also obtained under the same conditions. Then the survival curves were compared with those estimated by a microdosimetric model based on the spectra and the biological parameters for each cell line. The estimated α terms of the liner-quadratic model with a fixed β value reproduced the experimental results for cell irradiation for ion beams with LETs of less than 450 keV/μm, except in the region near the distal peak.

• Publisher: Radiation Research Society
• Subject: Cell Line / Cell lines / Cell Survival - radiation effects / Dose-Response Relationship, Radiation / Dosimetry / Energy value / Equipment Design / Equipment Failure Analysis / Fibroblasts - cytology / Fibroblasts - radiation effects / Heavy Ions / Humans / Ions / Irradiation / Light beams / Parametric models / Protons / Radiation Dosage / Radiometry - instrumentation / Radiometry - methods / Radiotherapy / Salivary Gland Neoplasms - pathology