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Comparison of effectiveness and safety of different haemostatic materials in patients undergoing transradial coronary intervention and diagnosis: a protocol for systematic review and network meta-analysis
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Comparison of effectiveness and safety of different haemostatic materials in patients undergoing transradial coronary intervention and diagnosis: a protocol for systematic review and network meta-analysis
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Comparison of effectiveness and safety of different haemostatic materials in patients undergoing transradial coronary intervention and diagnosis: a protocol for systematic review and network meta-analysis
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Journal Article
Comparison of effectiveness and safety of different haemostatic materials in patients undergoing transradial coronary intervention and diagnosis: a protocol for systematic review and network meta-analysis
2026
Overview
IntroductionEffective compression haemostasis is essential after transradial coronary procedures. However, evidence directly comparing different haemostatic materials remains limited. This study aims to compare and rank the efficacy and safety of different haemostatic materials used as adjuncts to compression after transradial coronary angiography and/or percutaneous coronary intervention, and to explore whether compression modality modifies their relative effects.Methods and analysisWe will systematically search nine databases (Cochrane Library, Embase, PubMed, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Data, VIP Database and Cumulative Index to Nursing and Allied Health Literature) for randomized controlled trials on post-transradial access (TRA) compression haemostasis with different haemostatic materials, from database inception to December 2025. Supplementary searches will be conducted in ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, academic search engines and reference lists of included studies. Two reviewers will independently perform study selection, data extraction and risk of bias assessment using the Cochrane Risk of Bias V.2 tool. A network meta-analysis will be conducted within a frequentist framework using Stata V.16.0. Heterogeneity, inconsistency, small-study effects, evidence quality, sensitivity and the assumption of transitivity will be assessed. Subgroup analyses will be performed according to compression modality (manual vs mechanical) and, where data permit, other prespecified study-level characteristics that may modify treatment effects.Ethics and disseminationAs this study is a systematic review and network meta-analysis based on published data, ethical approval is not required. The results will be disseminated through publication in a peer-reviewed journal and presentation at academic conferences.PROSPERO registration numberCRD420251250499.
Publisher
British Medical Journal Publishing Group,BMJ Publishing Group LTD,BMJ Publishing Group
