Asset Details
Do you wish to reserve the book?
Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses
Do you wish to request the book?
Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses
2016
Overview
PurposeRecent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of non-communicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors—particularly the fetal environment and postbirth living environment—on children's health, and to identify potential biomarkers for these effects.ParticipantsThe C-MACH consists of three hospital-based cohorts. The study participants are pregnant women at <13 weeks gestation. Women who underwent an examination in one of the three hospitals received an explanation of the study. The participants consented to completing questionnaire surveys and the collection and storage of biological and house/environmental samples. Participants were provided unique study numbers. All of the data and biological specimens will be stored in the Chiba University Center for Preventive Medical Sciences and Chiba University Center for Preventive Medical Sciences BioBank, respectively.Findings to dateConsent to participate was obtained from 433 women. Of these women, 376 women completed questionnaires in the early gestational period. The mean age was 32.5 (4.4) years. The mean body mass index (BMI) was 21.1 (3.0) kg/m2. Before pregnancy, 72.3% of the women had a BMI of 18.5–24.9 kg/m2. During early pregnancy, 5.0% of the participants smoked.Future plansPrimary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.
Publisher
BMJ Publishing Group LTD,BMJ Publishing Group
Subject
/ Child Health - statistics & numerical data
/ Consent
/ Developmental Disabilities - epidemiology
/ Disease
/ Environmental Pollutants - analysis
/ Epigenesis, Genetic - physiology
/ Female
/ Gastrointestinal Microbiome - physiology
/ Gene-Environment Interaction
/ Genomes
/ Humans
/ Infant
/ Maternal Exposure - statistics & numerical data
/ Maternal Health - statistics & numerical data
/ Mothers
/ Obesity
/ Polychlorinated Biphenyls - analysis
/ Pregnancy Complications - epidemiology
/ Prenatal Exposure Delayed Effects - epidemiology
