Journal Article

Endovascular therapy in patients with internal carotid artery occlusion and patent circle of Willis

Riegler, Christoph, Reich, Arno, Eckert, Bernd, Gregor, Arman, Thonke, Sven, Röther, Joachim, Schäfer, Jan-Hendrik, Thomalla, Götz, Gröschel, Klaus, Schell, Maximilian, Kleine, Justus F, Tiedt, Steffen, Nolte, Christian H, Flottmann, Fabian, von Rennenberg, Regina, Abruscato, Mario, Schellinger, Peter, Audebert, Heinrich J, Uphaus, Timo, Bollweg, Kerstin, Fiehler, Jens, Evangelidou, Evdokia, Ernemann, Ulrike, Siebert, Eberhard, Borggrefe, Jan, Zimmermann, Hanna, Braun, Michael, Keil, Fee, Poli, Sven, Nguyen, Thanh N, Nikoubashman, Omid, Maier, Ilko L., Hamann, Gerhard F

2024

Overview

BackgroundOcclusion of the internal carotid artery (ICA) may extend into the middle or anterior cerebral artery (ICA-T) or be confined to the intracranial (ICA-I) or extracranial segment (ICA-E). While there is excellent evidence for endovascular therapy (EVT) in ICA-T occlusions, studies on EVT in non-tandem ICA-I or ICA-E occlusions are scarce.ObjectiveTo characterize EVT-treated patients with ICA-I- and ICA-E occlusion by comparing them with ICA-T occlusions.MethodsThe German Stroke Registry (GSR), a national, multicenter, prospective registry was searched for EVT-treated patients with isolated ICA occlusion between June 2015 and December 2021. We stratified patients by ICA occlusion site: (a) ICA-T, (b) ICA-I, (c) ICA-E. Baseline factors, procedural variables, technical (modified Thrombolysis in Cerebral Infarction (mTICI)), and functional outcomes (modified Rankin scale score at 3 months) were analyzed.ResultsOf 13 082 GSR patients, 2588 (19.8%) presented with an isolated ICA occlusion, thereof 1946 (75.2%) ICA-T, 366 (14.1%) ICA-I, and 276 (10.7%) ICA-E patients. The groups differed in age (77 vs 76 vs 74 years, Ptrend=0.02), sex (53.4 vs 48.9 vs 43.1% female, Ptrend<0.01), and stroke severity (median National Institutes of Health Stroke Scale score at admission 17 vs 14 vs 13 points, Ptrend<0.001). In comparison with ICA-T occlusions, both ICA-I and ICA-E occlusions had lower rates of successful recanalization (mTICI 2b/3: 85.4% vs 80.4% vs 76.3%; aOR (95% CI for ICA-I vs ICA-T 0.71 (0.53 to 0.95); aOR (95% CI) for ICA-E vs ICA-T 0.57 (0.42 to 0.78)). In adjusted analyses, ICA-E occlusion was associated with worse outcome when compared with ICA-T occlusion (mRS ordinal shift, cOR (95% CI) 0.70 (0.52 to 0.93)).ConclusionPatient characteristics and outcomes differ substantially between ICA-T, ICA-I, and ICA-E occlusions. These results warrant further studies on EVT in ICA-I and ICA-E patients.

• Publisher: BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Publishing Group
• Subject: Aged / Aged, 80 and over / Angiography / Anticoagulants / Atherosclerosis / Carotid arteries / Carotid Artery, Internal - surgery / Carotid Stenosis - surgery / Cervical / Circle of Willis - diagnostic imaging / Circle of Willis - surgery / Clinical outcomes / Endovascular Procedures - methods / Ethics / Etiology / Female / Humans / Informed consent / Ischemic Stroke / Male / Medical imaging / Middle Aged / Patients / Prospective Studies / Registries / Stroke / Thrombectomy / Thrombolytic drugs / Treatment Outcome / Variables / Veins & arteries