Journal Article

Extended CPAP or low-flow nasal cannula for intermittent hypoxaemia in preterm infants: a 24-hour randomised clinical trial

Carlo, Waldemar A, Travers, Colm P, Ambalavanan, Namasivayam, Boateng, Ernestina O, Yazdi, Siamak, Nakhmani, Arie, Aban, Immaculada

2024

Overview

ObjectiveOptimal timing of continuous positive airway pressure (CPAP) cessation in preterm infants remains undetermined. We hypothesised that CPAP extension compared with weaning to low-flow nasal cannula (NC) reduces intermittent hypoxaemia (IH) and respiratory instability in preterm infants meeting criteria to discontinue CPAP.DesignSingle-centre randomised clinical trial.SettingLevel 4 neonatal intensive care unit.Patients36 infants <34 weeks’ gestation receiving CPAP≤5 cmH2O and fraction of inspired oxygen (FiO2) ≤0.30 and meeting respiratory stability criteria.InterventionsExtended CPAP was compared with weaning to low-flow NC (0.5 L/kg/min with a limit of 1.0 L/min) for 24 hours.OutcomesThe primary outcome was IH (number of episodes with SpO2<85% lasting ≥10 s). Secondary outcomes included: coefficient of variability of SpO2, proportion of time in various SpO2 ranges, episodes (≥10 s) with SpO2<80%, median cerebral and renal oxygenation, median effective FiO2, median transcutaneous carbon dioxide and bradycardia (<100/min for≥10 s).ResultsThe median (IQR) episodes of IH per 24-hour period was 20 (6–48) in the CPAP group and 76 (18–101) in the NC group (p=0.03). Infants continued on CPAP had less bradycardia, time with SpO2 <91% and <85%, and lower FiO2 (all p<0.05). There were no statistically significant differences in IH<80%, median transcutaneous carbon dioxide or median cerebral or renal oxygenation.ConclusionIn preterm infants meeting respiratory stability criteria for CPAP cessation, extended CPAP decreased IH, bradycardia and other hypoxaemia measures compared with weaning to low-flow NC during the 24-hour intervention.Trial registration number NCT04792099.

• Publisher: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health,BMJ Publishing Group LTD
• Subject: Bradycardia - therapy / Cannula / Carbon dioxide / Cardiac arrhythmia / Clinical trials / Continuous positive airway pressure / Continuous Positive Airway Pressure - methods / Female / Humans / Hypoxia - etiology / Hypoxia - therapy / Infant, Newborn / Infant, Premature / Infants / Intensive care / Intensive Care Units, Neonatal / Intervention / Male / Mann-Whitney U test / Neonatal care / Neonatology / Newborn babies / Original research / Oxygen Inhalation Therapy - instrumentation / Oxygen Inhalation Therapy - methods / Oxygen Saturation / Oxygenation / Physiology / Premature babies / Respiration / Respiratory distress syndrome / Respiratory Distress Syndrome, Newborn - therapy / Sepsis / Statistical analysis / Ventilator Weaning - methods / Ventilators / Weaning