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Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus
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Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus
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Journal Article
Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus
2009
Overview
Unlike other
Streptomyces
spp., the streptomycin producer
Streptomyces griseus
IFO13189 shows emergence of a small fraction of
rsmG
and
rpsL
mutants among spontaneous low- or high-level streptomycin-resistant mutants.
rsmG
, but not
rpsL
, mutants showed greater ability (two- to threefold) to produce streptomycin, accompanied by enhanced transcription of
metK
and
strR
, together with streptomycin biosynthetic genes, such as
strB1
,
strD
and
strF
, thus underlying the observed increase in streptomycin production in the
rsmG
mutants. Moreover,
rsmG
mutation was effective for activating the ‘silent’ or poorly expressed secondary metabolite–biosynthetic genes present in
S. griseus
.
Publisher
Nature Publishing Group UK,Nature Publishing Group
