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A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod
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A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod
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Journal Article
A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod
1998
Overview
Imiquimod, an immune response modifier, has been demonstrated to be safe and effective in the treatment of external genital and perianal warts caused by human papillomavirus (HPV). To identify the molecular mechanism(s) by which condylomata acuminata clear during topical treatment with imiquimod, wart skin biopsies were taken from patients before treatment, at treatment week 6, and at the end of treatment. Tissues were analyzed for HPV DNA and for mRNA of several cytokines and HPV gene products. Wart clearance was associated with evidence of tissue production of interferon-α, -β, and -γ and tumor necrosis factor-α. Regression of warts was strongly associated with a decrease in HPV DNA and in mRNA expression for both early and late viral proteins. Thus, topical imiquimod treatment of anogenital warts led to significant increases in local production of multiple interferon mRNAs and a significant reduction in virus load as measured by decreases in HPV DNA and mRNA for early HPV proteins.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Adult
/ Aminoquinolines - therapeutic use
/ Biological and medical sciences
/ Biopsies
/ Condylomata Acuminata - drug therapy
/ Condylomata Acuminata - immunology
/ Condylomata Acuminata - pathology
/ Condylomata Acuminata - virology
/ DNA
/ Erythema
/ Female
/ Genital Diseases, Female - drug therapy
/ Genital Diseases, Female - immunology
/ Genital Diseases, Female - pathology
/ Genital Diseases, Female - virology
/ Genital Diseases, Male - drug therapy
/ Genital Diseases, Male - immunology
/ Genital Diseases, Male - pathology
/ Genital Diseases, Male - virology
/ Humans
/ Interferon Inducers - therapeutic use
/ Male
/ Vehicles
/ Viral diseases of the genital and urinary system
/ Viruses
/ Warts
