Journal Article

2022 American College of Rheumatology/EULAR classification criteria for giant cell arteritis

Tsukamoto, Tatsuo, Mukhtyar, Chetan, Tesar, Vladimir, Kamali, Sevil, Sharma, Aman, Jayne, David, Grainger, Rebecca, Chakravarty, Kuntal, Mclaren, John, Tak, Paul-Peter, Rodrigues, Miguel, Diamantopoulos, Andreas, Pirila, Laura, Sznajd, Jan, Gewurz-Singer, Ora, Shahin, Amira, Moreno, Xavier Solanich, Liang, Kimberly, Yamagata, Kunihiro, Mason, Justin, Berglin, Ewa, Khalid, Sara, Robson, Joanna, Schiavon, Franco, Amano, Koichi, Matteson, Eric, Luqmani, Raashid A, Maw, Win Win, Azevedo, Elsa, Moiseev, Sergey, Merkel, Peter A., Das, Siddharth, Patel, Sanjeev, Dobashi, Hiroaki, Kono, Hajime, Wada, Takashi, Sreih, Antoine, Calabrese, Leonard, Henes, Jörg, Sunderkoetter, Cord, Honma, Sakae, Yumura, Wako, Harigai, Masayoshi, Moosig, Frank, Uchida, Shunya, Ikeda, Kei, Morgan, Ann, Santos, Ernestina, Daikeler, Thomas, Menon, Ajit, Tombetti, Enrico, Direskeneli, Haner, Quincey, Vicki, Neumann, Thomas, Pehlevan, Seval, Hassan, Alaa, Carette, Simon, Clarkson, Michael, Danda, Debashish, Albert, Daniel, Lamprecht, Peter, Baslund, Bo, Klocke, Rainer, Fujimoto, Shouichi, Song, Yeong-Wook, Hocevar, Alojzija, Hirahashi, Junichi, Luqman

2022

Overview

ObjectiveTo develop and validate updated classification criteria for giant cell arteritis (GCA).MethodsPatients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in six phases: (1) identification of candidate items, (2) prospective collection of candidate items present at the time of diagnosis, (3) expert panel review of cases, (4) data‐driven reduction of candidate items, (5) derivation of a points‐based risk classification score in a development data set and (6) validation in an independent data set.ResultsThe development data set consisted of 518 cases of GCA and 536 comparators. The validation data set consisted of 238 cases of GCA and 213 comparators. Age ≥50 years at diagnosis was an absolute requirement for classification. The final criteria items and weights were as follows: positive temporal artery biopsy or temporal artery halo sign on ultrasound (+5); erythrocyte sedimentation rate ≥50 mm/hour or C reactive protein ≥10 mg/L (+3); sudden visual loss (+3); morning stiffness in shoulders or neck, jaw or tongue claudication, new temporal headache, scalp tenderness, temporal artery abnormality on vascular examination, bilateral axillary involvement on imaging and fluorodeoxyglucose–positron emission tomography activity throughout the aorta (+2 each). A patient could be classified as having GCA with a cumulative score of ≥6 points. When these criteria were tested in the validation data set, the model area under the curve was 0.91 (95% CI 0.88 to 0.94) with a sensitivity of 87.0% (95% CI 82.0% to 91.0%) and specificity of 94.8% (95% CI 91.0% to 97.4%).ConclusionThe 2022 American College of Rheumatology/EULAR GCA classification criteria are now validated for use in clinical research.

• Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism,Elsevier Limited,BMJ Publishing Group
• Subject: Aorta / Arteritis / Atherosclerosis / Biopsy / Blood Sedimentation / C-reactive protein / Cardiovascular diseases / Case reports / Classification / Coronary vessels / Criteria / Datasets / Diagnosis / Erythrocyte sedimentation rate / Giant cell arteritis / Giant Cell Arteritis - diagnostic imaging / Giant Cell Arteritis - pathology / Humans / Jaw / Magnetic resonance imaging / Medical imaging / Middle Aged / Observational studies / Patients / Positron emission tomography / Prospective Studies / Rheumatology / Scalp / Systemic vasculitis / Temporal Arteries - diagnostic imaging / Temporal Arteries - pathology / Tomography / Ultrasonic imaging / Vasculitis / Vein & artery diseases