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Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China
by
Geng, Qing-Shan
, Wei, Xue-Biao
, Zhou, Yin-Lin
, Liu, Yuan-Hui
, Duan, Chong-Yang
, Guo, Yan-Song
, Yu, Dan-Qing
, Jiang, Lei
, Guo, Zhi-Qiang
, Chen, Zhu-Jun
, Lin, Chun-Ying
, Chen, Yi-Yue
, Chen, Wei
, Li, Jun
, Guo, Wei
, Luo, Jian-Fang
, Tan, Ning
, He, Peng-Cheng
, Li, Wen-Sheng
, Chen, Ji-Yan
, Chen, Peng-Yuan
in
Acute Coronary Syndrome
/ Acute coronary syndromes
/ Anemia
/ Angina pectoris
/ Angioplasty
/ Biomarkers
/ cardiology
/ Cardiovascular disease
/ Cardiovascular Medicine
/ China - epidemiology
/ Clinical outcomes
/ Cohort Studies
/ coronary heart disease
/ coronary intervention
/ Diabetes
/ Heart attacks
/ Heart failure
/ Hospitalization
/ Hospitals
/ Humans
/ Hypertension
/ Infections
/ Laboratories
/ Medical prognosis
/ Myocardial Infarction
/ Observational studies
/ Patients
/ Percutaneous Coronary Intervention - adverse effects
/ Stents
/ Treatment Outcome
2020
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Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China
by
Geng, Qing-Shan
, Wei, Xue-Biao
, Zhou, Yin-Lin
, Liu, Yuan-Hui
, Duan, Chong-Yang
, Guo, Yan-Song
, Yu, Dan-Qing
, Jiang, Lei
, Guo, Zhi-Qiang
, Chen, Zhu-Jun
, Lin, Chun-Ying
, Chen, Yi-Yue
, Chen, Wei
, Li, Jun
, Guo, Wei
, Luo, Jian-Fang
, Tan, Ning
, He, Peng-Cheng
, Li, Wen-Sheng
, Chen, Ji-Yan
, Chen, Peng-Yuan
in
Acute Coronary Syndrome
/ Acute coronary syndromes
/ Anemia
/ Angina pectoris
/ Angioplasty
/ Biomarkers
/ cardiology
/ Cardiovascular disease
/ Cardiovascular Medicine
/ China - epidemiology
/ Clinical outcomes
/ Cohort Studies
/ coronary heart disease
/ coronary intervention
/ Diabetes
/ Heart attacks
/ Heart failure
/ Hospitalization
/ Hospitals
/ Humans
/ Hypertension
/ Infections
/ Laboratories
/ Medical prognosis
/ Myocardial Infarction
/ Observational studies
/ Patients
/ Percutaneous Coronary Intervention - adverse effects
/ Stents
/ Treatment Outcome
2020
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Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China
by
Geng, Qing-Shan
, Wei, Xue-Biao
, Zhou, Yin-Lin
, Liu, Yuan-Hui
, Duan, Chong-Yang
, Guo, Yan-Song
, Yu, Dan-Qing
, Jiang, Lei
, Guo, Zhi-Qiang
, Chen, Zhu-Jun
, Lin, Chun-Ying
, Chen, Yi-Yue
, Chen, Wei
, Li, Jun
, Guo, Wei
, Luo, Jian-Fang
, Tan, Ning
, He, Peng-Cheng
, Li, Wen-Sheng
, Chen, Ji-Yan
, Chen, Peng-Yuan
in
Acute Coronary Syndrome
/ Acute coronary syndromes
/ Anemia
/ Angina pectoris
/ Angioplasty
/ Biomarkers
/ cardiology
/ Cardiovascular disease
/ Cardiovascular Medicine
/ China - epidemiology
/ Clinical outcomes
/ Cohort Studies
/ coronary heart disease
/ coronary intervention
/ Diabetes
/ Heart attacks
/ Heart failure
/ Hospitalization
/ Hospitals
/ Humans
/ Hypertension
/ Infections
/ Laboratories
/ Medical prognosis
/ Myocardial Infarction
/ Observational studies
/ Patients
/ Percutaneous Coronary Intervention - adverse effects
/ Stents
/ Treatment Outcome
2020
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Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China
Journal Article
Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from China
2020
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Overview
ObjectiveWe aimed to describe the association between in-hospital infection and prognosis among patients with non-ST elevation acute coronary syndrome (NSTE-ACS) who received percutaneous coronary intervention (PCI).DesignThis observational cohort originated from a database of patients with NSTE-ACS who underwent PCI from 1 January 2010 to 31 December 2014.SettingFive centres in South China.ParticipantsThis multicentre observational cohort study consecutively included 8197 patients with NSTE-ACS who received PCI. Only patients with adequate information to diagnose or rule out infection were included. Patients were excluded if they were diagnosed with a malignant tumour, were pregnant or presented with cardiogenic shock at the index date. Patients were grouped by whether they had in-hospital infection or not.Primary and secondary outcome measuresThe primary outcome was all-cause death and major bleeding during hospitalisation. The secondary outcomes included all-cause death and major bleeding during follow-up and in-hospital myocardial infarction.ResultsOf the 5215 patients, 206 (3.95%) acquired infection. Patients with infection had a higher rate of in-hospital all-cause death and major bleeding (4.4% vs 0.2% and 16.5% vs 1.2%, respectively; p<0.001). After adjusting for confounders, infection remained independently associated with in-hospital and long-term all-cause death (OR, 13.19, 95% CI 4.59 to 37.87; HR, 2.03, 95% CI 1.52 to 2.71; p<0.001) and major bleeding (OR, 10.24, 95% CI 6.17 to 16.98; HR, 5.31, 95% CI 3.49 to 8.08; p<0.001). A subgroup analysis confirmed these results.ConclusionsThe incidence of infection is low during hospitalisation, but is associated with worse in-hospital and long-term outcomes.
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