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Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report

by Dahl, Emilie Kristine , Seidelin, Jakob Benedict , Andersen, Janne Bayer , Ellebaek, Eva , Helms, Morten , Bjerrum, Jacob Tveiten , Holmstroem, Rikke Boedker , Nielsen, Henrik Vedel , Svane, Inge Marie

in Antibiotics / Antineoplastic Agents, Immunological - adverse effects / CANCER / Cancer therapies / Case reports / Colitis - drug therapy / Colitis - therapy / Cytokines / Diarrhea / Endoscopy / Enterocolitis - chemically induced / Enterocolitis - therapy / Fecal Microbiota Transplantation - adverse effects / Humans / IMMUNOTHERAPY / Inflammatory Bowel Disease / INFLAMMATORY BOWEL DISORDERS / Inhibitor drugs / INTESTINAL MICROBIOLOGY / Lymphocytes / Melanoma / Metastasis / Microbiota / MICROSCOPIC COLITIS / Monoclonal antibodies / Patients / Urinary tract diseases / Urinary tract infections / Urogenital system

2022

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Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report

2022

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Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report

2022

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Journal Article

Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report

Dahl, Emilie Kristine,

Seidelin, Jakob Benedict,

Andersen, Janne Bayer,

Ellebaek, Eva,

Helms, Morten,

Bjerrum, Jacob Tveiten,

Holmstroem, Rikke Boedker,

Nielsen, Henrik Vedel,

Svane, Inge Marie

2022

Overview

BackgroundImmune checkpoint inhibitors (ICIs) can induce a wide range of immune-related adverse events (irAEs), potentially affecting any organ. ICI-induced colitis is a frequently reported irAE, whereas enteritis is rare and not well documented.Case presentationWe are presenting a patient with metastatic melanoma who developed severe ICI-induced enterocolitis multirefractory for glucocorticoids, infliximab and vedolizumab, partially responding to faecal microbiota transplantation and final complete response to tofacitinib.ConclusionThis case supports that tofacitinib may be an(other) effective agent in managing multirefractory ICI-induced diarrhoea caused by colitis and/or enteritis.

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Publisher

BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Publishing Group

Subject

Antibiotics

/ Antineoplastic Agents, Immunological - adverse effects

/ CANCER

/ Cancer therapies

/ Case reports

/ Colitis - drug therapy

/ Colitis - therapy