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Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia

by Pinilla, Cristina , Álvarez, Josep Trenado , Six, Sophie , Bretagnol, Anne , Duburcq, Thibault , Hantson, Philippe , Cilloniz, Catia , Houard, Marion , Molina, Zaida , Herrera, Alejandro Cortes , Daunis, Jordi Vallés , Jacquier, Sophie , Legras, Annick , Cañas, Borja Suberviola , López Delgado, Juan Carlos , Saez, Ignacio , Colienne, Christine , Pouly, Olivier , Pouplet, Caroline , Jiménez, Ma José , Cirasa, Maria Teresa , Runge, Isabelle , Barbier, François , Clere-Jehl, Raphael , Calero, Jordi Codina , Desachy, Arnaud , Rodríguez, Ma Luisa , Emonet, Brian , Cuadra, Rosario , Errico, Livia , García, Ma Concepción , Calvet, Laure , Moreau, Anne Sophie , Fedou, Anne Laure , Sie, Daoud , Evrard, Bruno , François, Bruno , Helms, Julie , Large, Audrey , Mendiluce, Rafael Máñez , Krabseth, Hege-Merete , Lebert, Christine , Morimont, Philippe , Cracco, Christophe , Martin-Lefevre, Laurent , Iglesias, Mònica Marget , Bodí, Maria A , Zapatero, Diego Castanares , Marti, Antoni Torres , Paredes, Noemí , Lambermont, Bernard , Santos, Emilio Diaz , Lombardo, Eleuterio , Fiancette, Maud , Dargent, Auguste , Carpintero, Maite Arlabán , Agrifoglio, Alexander , Villare

in Aged / Anesthesia & intensive care / Anesthésie & soins intensifs / Apoptosis / Biomarkers / Biomarkers - blood / Clinical outcomes / Community-Acquired Infections / Critical Care / Cytokines / Female / Gene expression / Granulocytes / Human health sciences / Humans / Immune system / Inflammation / Intensive care / Ligands / Male / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cell Transplantation - methods / Mesenchymal Stem Cells / Mesenchymal Stem Cells - metabolism / Middle Aged / Pathophysiology / Patients / Plasma / Pneumonia / Pneumonia, Bacterial / Pneumonia, Bacterial - immunology / Proteins / Pulmonary and Respiratory Medicine / Pulmonary embolisms / Sciences de la santé humaine / Sepsis / Sepsis - immunology / Short Report / Statistical analysis / Stem cells / T cell receptors / Thromboembolism / Thrombosis / Tumor necrosis factor-TNF / Veins & arteries / Ventilators

2024

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Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia

2024

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2024

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Journal Article

Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia

Pinilla, Cristina,

Álvarez, Josep Trenado,

Six, Sophie,

Bretagnol, Anne,

Duburcq, Thibault,

Hantson, Philippe,

Cilloniz, Catia,

Houard, Marion,

Molina, Zaida,

Herrera, Alejandro Cortes,

Daunis, Jordi Vallés,

Jacquier, Sophie,

Legras, Annick,

Cañas, Borja Suberviola,

López Delgado, Juan Carlos,

Saez, Ignacio,

Colienne, Christine,

Pouly, Olivier,

Pouplet, Caroline,

Jiménez, Ma José,

Cirasa, Maria Teresa,

Runge, Isabelle,

Barbier, François,

Clere-Jehl, Raphael,

Calero, Jordi Codina,

Desachy, Arnaud,

Rodríguez, Ma Luisa,

Emonet, Brian,

Cuadra, Rosario,

Errico, Livia,

García, Ma Concepción,

Calvet, Laure,

Moreau, Anne Sophie,

Fedou, Anne Laure,

Sie, Daoud,

Evrard, Bruno,

François, Bruno,

Helms, Julie,

Large, Audrey,

Mendiluce, Rafael Máñez,

Krabseth, Hege-Merete,

Lebert, Christine,

Morimont, Philippe,

Cracco, Christophe,

Martin-Lefevre, Laurent,

Iglesias, Mònica Marget,

Bodí, Maria A,

Zapatero, Diego Castanares,

Marti, Antoni Torres,

Paredes, Noemí,

Lambermont, Bernard,

Santos, Emilio Diaz,

Lombardo, Eleuterio,

Fiancette, Maud,

Dargent, Auguste,

Carpintero, Maite Arlabán,

Agrifoglio, Alexander,

Villare

2024

Overview

Mesenchymal stem cells (MSC) have immune regulatory properties that may ameliorate pathophysiological processes in sepsis. We determined the effect of allogeneic adipose-derived MSCs (Cx611) on the host response during sepsis due to community-acquired bacterial pneumonia (CABP) by measuring 29 plasma biomarkers and blood transcriptomes at six time points in 82 patients randomised to two intravenous infusions of Cx611 or placebo. Cx611 treatment enhanced several endothelial cell and procoagulant response plasma biomarkers, and led to increased expression of pathways related to innate immunity, haemostasis and apoptosis. Cx611 infusion in sepsis due to CABP is associated with broad host response alterations.

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Publisher

BMJ Publishing Group Ltd and British Thoracic Society,BMJ Publishing Group LTD,BMJ Publishing Group

Subject

Aged

/ Anesthesia & intensive care

/ Anesthésie & soins intensifs