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Lung Function Decline and Outcomes in an Adult Population
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Journal Article
Lung Function Decline and Outcomes in an Adult Population
2006
Overview
Abstract
Rationale
Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality.
Objectives
To determine risk factors for and outcomes of rapid lung function decline in a cohort of adults in the United States.
Methods
We analyzed data from 15,536 adults aged 44–66 yr in the Atherosclerosis Risk in Communities study. We used Cox proportional hazard models to determine the risk of rapid lung function decline at 3 yr on mortality and COPD hospitalizations over the subsequent 8 yr.
Measurements and Main Results
Of those in the baseline cohort, 13,756 (88.5%) had spirometry at the Year 3 visit. The strongest risk factors for not having a follow-up spirometry were as follows: having Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 3 or 4 disease at baseline (adjusted odds ratio [OR] 2.8; 95% confidence interval [CI], 2.1–3.8), being black (adjusted OR, 2.4; 95% CI, 2.1–2.7), and being a current smoker (adjusted OR, 1.8; 95% CI, 1.5–2.0). Participants with GOLD stage 3 or 4 disease were also more likely to be in the most rapidly declining lung function quartile (adjusted OR, 3.7; 95% CI, 2.7–5.0). Overall, participants with the most rapidly declining lung function had a modestly increased risk of death (adjusted hazard ratio, 1.4; 95% CI, 1.2–1.7) and time to a COPD-related hospitalization (adjusted hazard ratio, 1.4; 95% CI, 1.2–1.8).
Conclusion
Rapid lung function decline was independently associated with a modest increased risk of COPD hospitalizations and deaths.
Publisher
Am Thoracic Soc,Oxford University Press,American Lung Association
Subject
/ Aged
/ Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
/ Biological and medical sciences
/ Chronic obstructive pulmonary disease
/ Chronic obstructive pulmonary disease, asthma
/ Dyspnea
/ Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
/ Exercise
/ Female
/ Humans
/ Male
/ Pulmonary Disease, Chronic Obstructive - complications
/ Pulmonary Disease, Chronic Obstructive - mortality
