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Anaphylactic shock and cardiac arrest caused by thiamine infusion
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Journal Article
Anaphylactic shock and cardiac arrest caused by thiamine infusion
2013
Overview
Parenteral thiamine has a very high safety profile. The most common adverse effect is local irritation; however, anaphylactic or anaphylactoid reactions may occur, mostly related to intravenous administration. We describe a 44-year-old man, a chronic alcoholic, who was admitted with alcohol intoxication and developed cardiac arrest due to anaphylactic shock following intravenous thiamine infusion. The patient was successfully resuscitated after 15 min and repeated epinephrine administrations. He was discharged in good health after 14 days. This case report emphasises both the importance of recognising the symptoms of anaphylaxis and the fact that facilities for treating anaphylaxis and cardiopulmonary resuscitation should be available when thiamine or for that matter, any drug is given in-hospital.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Publishing Group
Subject
/ Abdomen
/ Adult
/ Anaphylaxis - chemically induced
/ Cardiopulmonary resuscitation
/ CPR
/ Heart Arrest - chemically induced
/ Humans
/ Male
/ Patients
/ Sinuses
/ Thiamine - administration & dosage
/ Toxicity
/ Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions
/ Vitamin B Complex - administration & dosage
/ Vitamin B Complex - adverse effects
/ White
