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Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density
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Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density
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Journal Article
Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density
2005
Overview
Osteoporosis is a common condition characterized by reduced skeletal strength and increased susceptibility to fracture. The single major risk factor for osteoporosis is low bone mineral density (BMD) and strong evidence exists that genetic factors are in part responsible for an individual's BMD. A cohort of 40 multiplex Caucasian families selected through a proband with osteoporosis was genotyped for microsatellite markers spaced at an average of 10 cM, and linkage to femoral neck (FN), lumbar spine (LS) and trochanter (TR) BMD was analyzed using univariate and bivariate variance component linkage analysis. Maximum univariate multipoint lod-scores were 2.87 on chromosome 1p36 for FN BMD, 1.89 on 6q27 for TR BMD, and 2.15 on 7p15 for LS BMD. Results of bivariate linkage analysis were highly correlated with those of the univariate analysis, although generally less significant, suggesting the possibility that some of these susceptibility loci may exert pleiotropic effects on multiple skeletal sites.
Publisher
Springer International Publishing,Nature Publishing,Nature Publishing Group
Subject
/ Bioinformatics (Computational Biology)
/ Bioinformatik (beräkningsbiologi)
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Chromosome Mapping - methods
/ Femur
/ General aspects. Genetic counseling
/ Genetic Predisposition to Disease
/ Genetics
/ Genomes
/ Genotype
/ Humans
/ Investigative techniques, diagnostic techniques (general aspects)
/ Osteoarticular system. Muscles
/ Pedigree
/ Radiodiagnosis. Nmr imagery. Nmr spectrometry
/ Studies
