Journal Article

Outcome of hematopoietic stem cell transplantation in patients with atypical chronic myeloid leukemia

Beelen, D W, Ditschkowski, M, Steckel, N K, Koldehoff, M, Ottinger, H, Trenschel, R, Elmaagacli, A H, Peceny, R

2004

Overview

Atypical chronic myeloid leukemia (aCML) occurs rarely and is associated with a poor prognosis when treated with conventional chemotherapy. We evaluated the outcome of aCML after allogeneic hematopoietic stem cell transplantation (HSCT). Nine patients were transplanted from HLA-identical siblings (n = 4), HLA-compatible unrelated donors (n = 4) or twin brother (n = 1). Median follow-up was 55 months after transplant (range, 9.1-118.1 months). One patient who was transplanted in advanced disease with bone marrow from his twin brother relapsed 19 months post transplant. This patient was successfully retransplanted from the original donor. All patients remained in complete remission. Analysis of the leukocyte chimerism of peripheral white blood cells and bone marrow buffy coat cells by VNTR-polymerase chain reaction (PCR) and single-nucleotide polymorphism real-time PCR revealed complete chimerism in all patients who had received an allogeneic transplant. One patient suffering from cerebral toxoplasmosis died 9 months post transplant. All other patients were alive at the time of analysis. Our findings suggest that the outcome of allogeneic or syngeneic transplantation in patients with aCML may not be worse than the outcome of transplantation for BCR-ABL-positive CML.

• Publisher: Nature Publishing Group
• Subject: Adult / Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy / BCR-ABL protein / Biological and medical sciences / Bone marrow / Bone marrow transplantation / Bone marrow, stem cells transplantation. Graft versus host reaction / Buffy coat / Care and treatment / Chemotherapy / Chimerism / Chronic myeloid leukemia / Diagnosis / Female / Follow-Up Studies / Fusion protein / Genetic aspects / Graft vs Host Disease / Health aspects / Hematologic and hematopoietic diseases / Hematopoietic Stem Cell Transplantation - adverse effects / Hematopoietic Stem Cell Transplantation - methods / Hematopoietic stem cells / Histocompatibility antigen HLA / Humans / Leukemia / Leukemia, Myelogenous, Chronic, BCR-ABL Positive - classification / Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications / Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Leukocytes / Male / Medical sciences / Middle Aged / Myeloid leukemia / Nucleotides / Opportunistic Infections / Patient outcomes / Patients / Polymerase chain reaction / Polymorphism / Remission / Remission Induction / Retrospective Studies / Single-nucleotide polymorphism / Stem cell transplantation / Stem cells / Syngeneic grafts / Tissue Donors / Toxoplasmosis / Transfusions. Complications. Transfusion reactions. Cell and gene therapy / Transplantation / Transplantation Chimera / Transplantation, Homologous / Transplantation, Isogeneic / Treatment Outcome / Twins