Journal Article

Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity

Dove, Fiona, Cassidy, Deirdre B, Belch, Jill JF, Summersgill, Jennifer, Colhoun, Helen M, Weir-McCall, Jonathan R, Khan, Faisel, Thakur, Arsh, Matthew, Shona Z, Gandy, Stephen J, Houston, J Graeme, Adams, Fiona

2017

Overview

Background Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf.-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements. Methods One hundred fourteen study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) ( n  = 23), T2DM without CVD ( n  = 41), CVD without T2DM ( n  = 25) and a control group ( n  = 25). All participants underwent cf.-PWV, cardiac MRI and whole body MR angiography(WB-MRA). 90 study participants also underwent aortic PWV using MRI. cf.-PWV EXT was performed using a SphygmoCor device (Atcor Medical, West Ryde, Australia). The true intra-arterial pathlength was measured using the WB-MRA and then used to recalculate the cf.-PWV EXT to give a cf.-PWV MRA . Results Distance measurements were significantly lower on WB-MRA than on external tape measure (mean diff = −85.4 ± 54.0 mm, p  < 0.001). MRI-PWV was significantly lower than cf.-PWV EXT (MRI-PWV = 8.1 ± 2.9 vs. cf.-PWV EXT  = 10.9 ± 2.7 ms −1 , p  < 0.001). When cf.-PWV was recalculated using the inter-arterial distance from WB-MRA, this difference was significantly reduced but not lost (MRI-PWV = 8.1 ± 2.9 ms −1 vs. cf.-PWV MRA 9.1 ± 2.1 ms −1 , mean diff = −0.96 ± 2.52 ms −1 , p  = 0.001). Recalculation of the PWV increased correlation with age and pulse pressure. Conclusion Differences in cf.-PWV and MRI PWV can be predominantly but not entirely explained by inaccuracies introduced by the use of simple surface measurements to represent the convoluted arterial path between the carotid and femoral arteries.

• Publisher: BioMed Central,Springer Nature B.V,BMC
• Subject: Aged / Angiography / Angiology / Aorta / Aorta - diagnostic imaging / Aorta - physiopathology / Arteriosclerosis / Blood Transfusion Medicine / Cardiac Surgery / Cardiology / Cardiovascular / Cardiovascular disease / Cardiovascular Diseases - diagnostic imaging / Cardiovascular Diseases - physiopathology / Carotid Arteries - diagnostic imaging / Carotid Arteries - physiopathology / Diabetes / Diabetes mellitus / Diabetes Mellitus, Type 2 - complications / Diabetes Mellitus, Type 2 - diagnosis / Diabetic Angiopathies - diagnostic imaging / Diabetic Angiopathies - etiology / Diabetic Angiopathies - physiopathology / Electrocardiography / Female / Femoral artery / Femoral Artery - diagnostic imaging / Femoral Artery - physiopathology / Femur / Heart diseases / Humans / Hypertension / Hypertension and Cardiovascular Risk / Internal Medicine / Internet / Magnetic Resonance Angiography / Magnetic resonance imaging / Male / Manometry / Medical imaging / Medicine / Medicine & Public Health / Middle Aged / MRI / NMR / Nuclear magnetic resonance / Predictive Value of Tests / Pulse Wave Analysis - methods / PWV / Regional Blood Flow / Reproducibility of Results / Research Article / Vascular Stiffness / Velocity / Whole Body Imaging