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Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome
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Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome
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Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome
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Journal Article
Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome
2009
Overview
Objectives:To determine tolerance rates to cow’s milk and soy and to suggest guidelines for follow-up oral food challenges (FU-OFCs) in infantile food protein-induced enterocolitis syndrome (FPIES).Methods:The authors analysed the data of 23 patients with infantile FPIES who underwent two or more FU-OFCs and were followed up until over 2 years of age. The first FU-OFCs were performed at 6 months of age, and patients were randomly allocated to cow’s milk (n = 11) or soy (n = 12) challenge starting groups. Second and third FU-OFCs were performed at 2-month intervals in a crossed and switched-over manner.Results:Tolerance rates to cow’s milk and soy were 27.3% and 75.0% at 6 months of age, 41.7% and 90.9% at 8 months and 63.6% and 91.7% at 10 months, respectively. Patients outgrew cow’s milk and soy intolerance at age 20 and 14 months.Conclusions:In infantile FPIES, the first FU-OFC should be performed with soy at 6–8 months of age and cow’s milk FU-OFC should be conducted at over 12 months of age. Infants with FPIES were observed to outgrow food sensitivities during the first 2 years of life.
Publisher
BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health,BMJ Publishing Group,BMJ Publishing Group Ltd,BMJ Publishing Group LTD
Subject
/ Age
/ Allergy
/ Biological and medical sciences
/ Cheese
/ Diarrhea
/ Diet
/ Female
/ Food
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Humans
/ Immunoglobulin E - immunology
/ Infant
/ Male
/ Milk
/ Milk Proteins - adverse effects
/ Neonates
/ Patients
/ Pediatric food hypersensitivity
/ Practice Guidelines as Topic
/ Proteins
/ Public health. Hygiene-occupational medicine
/ Soybean Proteins - adverse effects
/ Soybean Proteins - immunology
/ Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
/ Studies
/ Syndrome
/ Vomiting
