Journal Article

Pemphigus in India

De, Dipankar, Kanwar, Amrinder J

2011

Overview

Pemphigus is a chronic epidermal immunobullous disease with potentially fatal outcome. The journey of literature on pemphigus in India has come a long way in last five decades. Pemphigus in Indian patients has unique genetic, clinical, and epidemiological differences from those in the Western countries. Corticosteroids remain the mainstay of treatment for pemphigus. Dexamethasone-cyclophosphamide pulse therapy has revolutionized the management of pemphigus in India and abroad for nearly 3 decades now. Corticosteroid-based treatment, along with adjuvants, has significantly brought down the high mortality rates that had been observed in precorticosteroid era. Present day research is largely based on elucidating the pathogenesis beyond the antidesmoglein antibodies, and newer diagnostic and treatment approaches. In this article, we review various aspects of literature on pemphigus in India, on Indians abroad, or literature from other countries that are considered relevant to the topic.

• Publisher: Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL),Medknow Publications and Media Pvt. Ltd,Scientific Scholar
• Subject: Adrenal Cortex Hormones - administration & dosage / Animals / Autoimmune diseases / Care and treatment / Corticosteroids / Cyclophosphamide - administration & dosage / Dexamethasone - administration & dosage / Diagnosis / Drug therapy / Drug Therapy, Combination / Epidemiology / Haplotypes / Health aspects / Humans / India - epidemiology / Infections / Mortality / Pathogenesis / Pemphigus / Pemphigus - diagnosis / Pemphigus - epidemiology / Pemphigus - therapy / Pemphigus, clinical features, diagnosis, management, India / Skin / Studies / Viral infections