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Anticholinergic Therapy vs. OnabotulinumtoxinA for Urgency Urinary Incontinence
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Anticholinergic Therapy vs. OnabotulinumtoxinA for Urgency Urinary Incontinence
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Journal Article
Anticholinergic Therapy vs. OnabotulinumtoxinA for Urgency Urinary Incontinence
2012
Overview
In a trial comparing onabotulinumtoxinA with an anticholinergic drug, both reduced urgency incontinence episodes. The rates of urinary retention and urinary tract infections were higher with onabotulinumtoxinA, but the rate of dry mouth was higher with anticholinergics.
Urgency urinary incontinence is characterized by unpredictable loss of urine; it is a prevalent condition that occurs disproportionately in women, affecting up to 19% of older women in the United States.
1
Anticholinergic medications are used as the primary treatment for this condition. A recent systematic review of trials comparing treatments for urgency urinary incontinence showed that none of the six drugs evaluated was superior to another in treating the condition and that current evidence was insufficient to guide the choice among other therapies, including injections of botulinum toxin.
2
OnabotulinumtoxinA is effective in treating urgency urinary incontinence that is resistant to . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Bladder
/ Botulinum Toxins, Type A - adverse effects
/ Botulinum Toxins, Type A - therapeutic use
/ Cholinergic Antagonists - adverse effects
/ Cholinergic Antagonists - therapeutic use
/ Female
/ Humans
/ Nephrology. Urinary tract diseases
/ Nortropanes - adverse effects
/ Nortropanes - therapeutic use
/ Quinuclidines - adverse effects
/ Quinuclidines - therapeutic use
/ Tetrahydroisoquinolines - adverse effects
/ Tetrahydroisoquinolines - therapeutic use
/ Urinary Incontinence, Urge - drug therapy
/ Urinary Retention - chemically induced
/ Urinary system involvement in other diseases. Miscellaneous
/ Urinary Tract Infections - etiology
