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Photothermal therapy of cancer cells mediated by blue hydrogel nanoparticles
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Photothermal therapy of cancer cells mediated by blue hydrogel nanoparticles
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Journal Article
Photothermal therapy of cancer cells mediated by blue hydrogel nanoparticles
2013
Overview
The aim of this study was to investigate
the utility of biologically compatible, nontoxic and cell-specific targetable hydrogel nanoparticles (NPs), which have Coomassie
Brilliant Blue G dye (Sigma-Aldrich, MO, USA) covalently linked into their polyacrylamide matrix, as candidates for photothermal therapy (PTT) of cancer cells.
Hydrogel NPs with Coomassie Brilliant Blue G dye covalently linked into their polyacrylamide matrix were fabricated using a reverse micelle microemulsion polymerization method and were found to be 80-95 nm in diameter, with an absorbance value of 0.52. PTT-induced hyperthermia/thermolysis was achieved at 37°C using an inexpensive, portable, light-emitting diode array light source (590 nm, 25 mW/cm
).
Hydrogel NPs with Coomassie Brilliant Blue G dye linked into their polyacrylamide matrix are effective in causing PTT-induced thermolysis in immortalized human cervical cancer cell line (HeLa) cells for varying NP concentrations and treatment times. These multifunctional particles have previously been used in cancer studies to enable delineation, for glioma surgery and in photoacoustic imaging studies. The addition of the PTT function would enable a three-pronged theranostic approach to cancer medicine, such as guided tumor surgery with intra-operative photoacoustic imaging and intra-operative PTT.
Original submitted 21 May 2012; Revised submitted 13 September 2012
Publisher
Future Medicine Ltd,Future Medicine
Subject
Acrylic Resins - administration & dosage
/ Biological and medical sciences
/ Cancer
/ Female
/ Humans
/ Hydrogels - administration & dosage
/ Methods
/ Nanoparticles - administration & dosage
/ Photoradiation therapy and photosensitizing agent
/ Rosaniline Dyes - administration & dosage
/ Treatment with physical agents
/ Tumors
