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TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
by
Ru, Jinlong
, Guo, Zihu
, Zhou, Wei
, Tao, Weiyang
, Yang, Yinfeng
, Wang, Yonghua
, Xu, Xue
, Li, Bohui
, Li, Yan
, Huang, Chao
, Li, Peng
, Li, Pidong
, Wang, Jinan
, Yang, Ling
in
Chemistry
/ Chemistry and Materials Science
/ Chinese medicine
/ Computational Biology/Bioinformatics
/ Computer Applications in Chemistry
/ Disease
/ Documentation and Information in Chemistry
/ Drug discovery
/ Drugs
/ Folk medicine
/ Herbal medicine
/ Medicine, Botanic
/ Medicine, Chinese
/ Medicine, Herbal
/ Permeability
/ Pharmacology
/ Theoretical and Computational Chemistry
2014
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TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
by
Ru, Jinlong
, Guo, Zihu
, Zhou, Wei
, Tao, Weiyang
, Yang, Yinfeng
, Wang, Yonghua
, Xu, Xue
, Li, Bohui
, Li, Yan
, Huang, Chao
, Li, Peng
, Li, Pidong
, Wang, Jinan
, Yang, Ling
in
Chemistry
/ Chemistry and Materials Science
/ Chinese medicine
/ Computational Biology/Bioinformatics
/ Computer Applications in Chemistry
/ Disease
/ Documentation and Information in Chemistry
/ Drug discovery
/ Drugs
/ Folk medicine
/ Herbal medicine
/ Medicine, Botanic
/ Medicine, Chinese
/ Medicine, Herbal
/ Permeability
/ Pharmacology
/ Theoretical and Computational Chemistry
2014
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![TCMSP: a database of systems pharmacology for drug discovery from herbal medicines](https://www.mbrl.ae/o/mbrl-theme/images/site-assets/generic/no-book-image.png)
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
by
Ru, Jinlong
, Guo, Zihu
, Zhou, Wei
, Tao, Weiyang
, Yang, Yinfeng
, Wang, Yonghua
, Xu, Xue
, Li, Bohui
, Li, Yan
, Huang, Chao
, Li, Peng
, Li, Pidong
, Wang, Jinan
, Yang, Ling
in
Chemistry
/ Chemistry and Materials Science
/ Chinese medicine
/ Computational Biology/Bioinformatics
/ Computer Applications in Chemistry
/ Disease
/ Documentation and Information in Chemistry
/ Drug discovery
/ Drugs
/ Folk medicine
/ Herbal medicine
/ Medicine, Botanic
/ Medicine, Chinese
/ Medicine, Herbal
/ Permeability
/ Pharmacology
/ Theoretical and Computational Chemistry
2014
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TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
![TCMSP: a database of systems pharmacology for drug discovery from herbal medicines](https://syndetics.com/index.aspx?isbn=/mc.gif&issn=1758-2946&client=MBRL&type=mbrl)
Journal Article
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
2014
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Overview
Background
Modern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs. In an effort to promote integration of both sides and to accelerate the drug discovery from herbal medicines, an efficient systems pharmacology platform that represents ideal information convergence of pharmacochemistry, ADME properties, drug-likeness, drug targets, associated diseases and interaction networks, are urgently needed.
Description
The traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was built based on the framework of systems pharmacology for herbal medicines. It consists of all the 499 Chinese herbs registered in the Chinese pharmacopoeia with 29,384 ingredients, 3,311 targets and 837 associated diseases. Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier and Lipinski’s rule of five are provided for drug screening and evaluation. TCMSP also provides drug targets and diseases of each active compound, which can automatically establish the compound-target and target-disease networks that let users view and analyze the drug action mechanisms. It is designed to fuel the development of herbal medicines and to promote integration of modern medicine and traditional medicine for drug discovery and development.
Conclusions
The particular strengths of TCMSP are the composition of the large number of herbal entries, and the ability to identify drug-target networks and drug-disease networks, which will help revealing the mechanisms of action of Chinese herbs, uncovering the nature of TCM theory and developing new herb-oriented drugs. TCMSP is freely available at
http://sm.nwsuaf.edu.cn/lsp/tcmsp.php
.
Publisher
Springer International Publishing,BioMed Central Ltd,Springer Nature B.V,BioMed Central
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