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Elg1 forms an alternative RFC complex important for DNA replication and genome integrity
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Elg1 forms an alternative RFC complex important for DNA replication and genome integrity
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Journal Article
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity
2003
Overview
Genome‐wide synthetic genetic interaction screens with mutants in the
mus81
and
mms4
replication fork‐processing genes identified a novel replication factor C (RFC) homolog, Elg1, which forms an alternative RFC complex with Rfc2–5. This complex is distinct from the DNA replication RFC, the DNA damage checkpoint RFC and the sister chromatid cohesion RFC. As expected from its genetic interactions,
elg1
mutants are sensitive to DNA damage. Elg1 is redundant with Rad24 in the DNA damage response and contributes to activation of the checkpoint kinase Rad53. We find that
elg1
mutants display DNA replication defects and genome instability, including increased recombination and mutation frequencies, and minichromosome maintenance defects. Mutants in
elg1
show genetic interactions with pathways required for processing of stalled replication forks, and are defective in recovery from DNA damage during S phase. We propose that Elg1‐RFC functions both in normal DNA replication and in the DNA damage response.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Springer Nature B.V,Oxford University Press
Subject
/ Carrier Proteins - metabolism
/ DNA
/ DNA Replication - drug effects
/ DNA Replication - radiation effects
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - metabolism
/ EMBO13
/ Gene Expression Regulation, Fungal
/ Genome
/ Mutants
/ Mutation
/ Nucleic Acid Synthesis Inhibitors - pharmacology
/ Protein-Serine-Threonine Kinases - metabolism
/ S Phase
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae - growth & development
/ Saccharomyces cerevisiae - metabolism
