Journal Article

Monocyte/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment

Fan, Zeyuan, Jian, Xinwen, Li, Li, Li, Yang, Ji, Hanhua, Liu, Tao, Zuo, Bo

2017

Overview

Background We aimed to explore whether monocyte to lymphocyte ratio (MLR) provides predictive value of the lesion severity in patients with coronary artery disease (CAD). Methods Five hundred forty-three patients undergoing coronary angiography were analyzed in this retrospective study. Patients with coronary stenosis were divided into three groups on the basis of Syntax score. The control group consisted of patients with normal coronary arteries. MLR was calculated by dividing monocytes count by lymphocytes count obtained from routine blood examination. Multivariate logistic analysis was used to assess risk factors of CAD. Ordinal logistic regression analysis was used to assess the relationship between MLR and the lesion severity of coronary arteries. Results MLR was found to be an independent risk factor of the presence of CAD (OR: 3.94, 95% CI: 1.20–12.95) and a predictor of the lesion severity (OR: 2.05, 95% CI: 1.15–3.66). Besides, MLR was positively correlated with Syntax score( r  = 0.437, p  < 0.001). In the receiver-operating characteristic (ROC) curve analysis, MLR, with an optimal cut-off value of 0.25, predicted the severe coronary lesion with a sensitivity of 60.26% and specificity of 78.49%. Conclusions MLR was an independent risk factor of the presence of CAD, and a predictor of the lesion severity. Compared to neutrophil to lymphocyte ratio (NLR), MLR has better performance to reflect the severity of coronary lesion.

• Publisher: BioMed Central,Springer Nature B.V,BMC
• Subject: Acute coronary syndromes / Age / Aged / Angiography / Angiology / Angioplasty / Area Under Curve / Atherosclerosis / Aviation / Blood Transfusion Medicine / Cardiac Surgery / Cardiology / Cardiovascular disease / Cholesterol / Clinical outcomes / Coronary Angiography / Coronary artery / Coronary artery disease / Coronary Artery Disease - blood / Coronary Artery Disease - diagnostic imaging / Coronary Stenosis - blood / Coronary Stenosis - diagnostic imaging / Coronary vessels / Coronary Vessels - diagnostic imaging / Diabetes / Family medical history / Fasting / Female / Heart attacks / Heart diseases / Hospitals / Humans / Hypertension / Internal Medicine / Laboratories / Logistic Models / Lymphocyte Count / Lymphocytes / Male / Medicine / Medicine & Public Health / Middle Aged / Monocyte to lymphocyte ratio / Monocytes / Mortality / Multivariate Analysis / Neutrophils / Odds Ratio / Predictive Value of Tests / Prognosis / Reproducibility of Results / Research Article / Retrospective Studies / Risk Factors / ROC Curve / Severity of Illness Index / Stenosis / Studies / Syntax score / Tuberculosis / Variables