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Lamina-specific axonal projections in the zebrafish tectum require the type IV collagen Dragnet
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Lamina-specific axonal projections in the zebrafish tectum require the type IV collagen Dragnet
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Journal Article
Lamina-specific axonal projections in the zebrafish tectum require the type IV collagen Dragnet
2007
Overview
The mechanisms underlying the precise targeting of tectal layers by ingrowing retinal axons are largely unknown. In zebrafish, individual axons choose one of four retinorecipient layers upon entering the tectum and remain restricted to this layer, despite continual remodeling and shifting of their terminal arbors. In
dragnet
mutants, by contrast, a large fraction of retinal axons aberrantly trespass between layers or form terminal arbors that span two layers. The
dragnet
gene,
drg
, encodes collagen IV
α5
(Col4a5), a basement membrane component lining the surface of the tectum. Heparan sulfate proteoglycans (HSPGs) are normally associated with the tectal basement membrane but are dispersed in the
dragnet
mutant tectum. Zebrafish
boxer
(
extl3
) mutants, which are deficient in HSPG synthesis, show laminar targeting defects similar to those in
dragnet
. Our results show that the collagen IV sheet anchors secreted factors at the surface of the tectum, which serve as guidance cues for retinal axons.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Animals, Genetically Modified
/ Axons
/ Basement Membrane - metabolism
/ Biomedical and Life Sciences
/ Collagen
/ Collagen Type IV - physiology
/ Extracellular Matrix - genetics
/ Gene Expression Regulation - genetics
/ Green Fluorescent Proteins - biosynthesis
/ Green Fluorescent Proteins - genetics
/ Heparan Sulfate Proteoglycans - metabolism
/ Superior Colliculi - physiology
/ Visual Pathways - physiology
