Asset Details
Do you wish to reserve the book?
Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
Do you wish to request the book?
Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
2015
Overview
The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using overexpression and knockdown constructs. Activation of the Notch signaling pathway by Notch1 or Jagged1 overexpression enhanced the migration, invasiveness and angiogenic ability of endothelial progenitor cells. Suppression of the Notch signaling pathway with Notch1 or Jagged1 si RNAs reduced the migratory capacity, invasiveness and angiogenic ability of endothelial progenitor cells. Activation of the Notch signaling pathway in vivo in a rat model of mild traumatic brain injury promoted neurovascular repair. These findings suggest that the activation of the Notch signaling pathway promotes blood vessel formation and tissue repair after brain trauma.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Department of Neurosurgery, the First People’s Hospital of ZunYi/the Third Afifliated Hospital of ZunYi Medical College, Zunyi, Guizhou Province, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
