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Methodological and clinical implications of a three-in-one Russian doll design for tracking health trajectories and improving health and function through innovative exercise treatments in adults with disability
by
Mehta, Tapan
, Rimmer, James H.
, Herman, Cassandra
, Wingo, Brooks
, Fontaine, Kevin
in
Adult
/ Disabilities
/ Disabled Persons - psychology
/ Disabled Persons - rehabilitation
/ Exercise
/ Exercise - physiology
/ Exercise rehabilitation
/ Exercise Therapy - methods
/ Female
/ Health
/ Health aspects
/ Health Sciences
/ Health Status
/ Humans
/ Longitudinal
/ Longitudinal Studies
/ Male
/ Medicine
/ Medicine & Public Health
/ Nervous System Diseases - physiopathology
/ Nervous System Diseases - psychology
/ Nervous System Diseases - rehabilitation
/ Neurologic disability
/ Outcome Assessment, Health Care - methods
/ Prospective Studies
/ Quality of Life - psychology
/ Recovery of Function - physiology
/ Research Design
/ Statistical Theory and Methods
/ Statistics for Life Sciences
/ Study design
/ Study Protocol
/ Theory of Medicine/Bioethics
2018
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Methodological and clinical implications of a three-in-one Russian doll design for tracking health trajectories and improving health and function through innovative exercise treatments in adults with disability
by
Mehta, Tapan
, Rimmer, James H.
, Herman, Cassandra
, Wingo, Brooks
, Fontaine, Kevin
in
Adult
/ Disabilities
/ Disabled Persons - psychology
/ Disabled Persons - rehabilitation
/ Exercise
/ Exercise - physiology
/ Exercise rehabilitation
/ Exercise Therapy - methods
/ Female
/ Health
/ Health aspects
/ Health Sciences
/ Health Status
/ Humans
/ Longitudinal
/ Longitudinal Studies
/ Male
/ Medicine
/ Medicine & Public Health
/ Nervous System Diseases - physiopathology
/ Nervous System Diseases - psychology
/ Nervous System Diseases - rehabilitation
/ Neurologic disability
/ Outcome Assessment, Health Care - methods
/ Prospective Studies
/ Quality of Life - psychology
/ Recovery of Function - physiology
/ Research Design
/ Statistical Theory and Methods
/ Statistics for Life Sciences
/ Study design
/ Study Protocol
/ Theory of Medicine/Bioethics
2018
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Methodological and clinical implications of a three-in-one Russian doll design for tracking health trajectories and improving health and function through innovative exercise treatments in adults with disability
by
Mehta, Tapan
, Rimmer, James H.
, Herman, Cassandra
, Wingo, Brooks
, Fontaine, Kevin
in
Adult
/ Disabilities
/ Disabled Persons - psychology
/ Disabled Persons - rehabilitation
/ Exercise
/ Exercise - physiology
/ Exercise rehabilitation
/ Exercise Therapy - methods
/ Female
/ Health
/ Health aspects
/ Health Sciences
/ Health Status
/ Humans
/ Longitudinal
/ Longitudinal Studies
/ Male
/ Medicine
/ Medicine & Public Health
/ Nervous System Diseases - physiopathology
/ Nervous System Diseases - psychology
/ Nervous System Diseases - rehabilitation
/ Neurologic disability
/ Outcome Assessment, Health Care - methods
/ Prospective Studies
/ Quality of Life - psychology
/ Recovery of Function - physiology
/ Research Design
/ Statistical Theory and Methods
/ Statistics for Life Sciences
/ Study design
/ Study Protocol
/ Theory of Medicine/Bioethics
2018
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Methodological and clinical implications of a three-in-one Russian doll design for tracking health trajectories and improving health and function through innovative exercise treatments in adults with disability
Journal Article
Methodological and clinical implications of a three-in-one Russian doll design for tracking health trajectories and improving health and function through innovative exercise treatments in adults with disability
2018
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Overview
Background
Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues.
Methods
Our Russian doll framework encompasses three study phases. Phase 1 involves prospectively following a cohort of participants with disability to examine the relationships between rates of health and functional deficits (e.g., pain, fatigue, deconditioning), functional measures (e.g., cardiorespiratory endurance, strength, balance), and environmental and sociocultural factors. In Phase 2, eligible participants with neurologic disability from Phase 1 (in our example, individuals with multiple sclerosis) are screened and randomized to a clinical exercise efficacy trial. In Phase 3, study participants are enrolled in a home-based teleexercise trial to test the feasibility and replicability of delivering the clinical exercise study in the home.
Discussion
This unique three-in-one Russian doll framework serves as a foundation for informing and guiding researchers and clinicians in treating certain health and functional deficits in people with neurologic disability using exercise as a primary treatment modality in both the clinical and home settings. It offers a unique perspective for understanding the critical issues of functioning, health maintenance and quality of life for people with neurologic disability across a longitudinal framework.
Trial registration
Study 2
ClinicalTrials.gov
identifier
NCT02533882
(retroactively registered 03/06/2015). Study 3
ClinicalTrials.gov
identifier
NCT03108950
(retroactively registered 04/05/2017).
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Disabled Persons - psychology
/ Disabled Persons - rehabilitation
/ Exercise
/ Female
/ Health
/ Humans
/ Male
/ Medicine
/ Nervous System Diseases - physiopathology
/ Nervous System Diseases - psychology
/ Nervous System Diseases - rehabilitation
/ Outcome Assessment, Health Care - methods
/ Quality of Life - psychology
/ Recovery of Function - physiology
/ Statistical Theory and Methods
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