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Primitive endoderm differentiation: from specification to epithelium formation
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Journal Article
Primitive endoderm differentiation: from specification to epithelium formation
2014
Overview
In amniotes, primitive endoderm (PrE) plays important roles not only for nutrient support but also as an inductive tissue required for embryo patterning. PrE is an epithelial monolayer that is visible shortly before embryo implantation and is one of the first three cell lineages produced by the embryo. We review here the molecular mechanisms that have been uncovered during the past 10 years on PrE and epiblast cell lineage specification within the inner cell mass of the blastocyst and on their subsequent steps of differentiation.
Publisher
The Royal Society,Royal Society, The
Subject
/ Animals
/ Cell Differentiation - physiology
/ Embryology and Organogenesis
/ Embryonic Development - physiology
/ Fibroblast Growth Factor 4 - metabolism
/ Gene Expression Regulation, Developmental - genetics
/ Gene Expression Regulation, Developmental - physiology
/ Homeodomain Proteins - physiology
/ Mice
/ Review
