Asset Details
Do you wish to reserve the book?
Social interactions among epithelial cells during tracheal branching morphogenesis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Social interactions among epithelial cells during tracheal branching morphogenesis
Do you wish to request the book?
Social interactions among epithelial cells during tracheal branching morphogenesis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Social interactions among epithelial cells during tracheal branching morphogenesis
2006
Overview
Genetic mosaic analysis in
Drosophila melanogaster
shows that there are two classes of cells in the budding tracheal branches: those that migrate to the tip, and those that follow these lead cells and form a tube. The position of the cell results from competition within the population, with those expressing the highest level of FGF taking the lead positions at the tip, and the others forming the branch stalk.
Many organs are composed of tubular networks that arise by branching morphogenesis in which cells bud from an epithelium and organize into a tube
1
,
2
,
3
. Fibroblast growth factors (FGFs) and other signalling molecules have been shown to guide branch budding and outgrowth
4
,
5
,
6
,
7
, but it is not known how epithelial cells coordinate their movements and morphogenesis. Here we use genetic mosaic analysis in
Drosophila melanogaster
to show that there are two functionally distinct classes of cells in budding tracheal branches: cells at the tip that respond directly to Branchless FGF and lead branch outgrowth, and trailing cells that receive a secondary signal to follow the lead cells and form a tube. These roles are not pre-specified; rather, there is competition between cells such that those with the highest FGF receptor activity take the lead positions, whereas those with less FGF receptor activity assume subsidiary positions and form the branch stalk. Competition appears to involve Notch-mediated lateral inhibition that prevents extra cells from assuming the lead. There may also be cooperation between budding cells, because in a mosaic epithelium, cells that cannot respond to the chemoattractant, or respond only poorly, allow other cells in the epithelium to move ahead of them.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Biological and medical sciences
/ Drosophila melanogaster - cytology
/ Drosophila melanogaster - embryology
/ Drosophila melanogaster - genetics
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Epithelial Cells - metabolism
/ Fundamental and applied biological sciences. Psychology
/ Genetics
/ Humanities and Social Sciences
/ Insecta
/ Insects
/ letter
/ Life cycle. Embryology. Development
/ Protein-Tyrosine Kinases - genetics
/ Protein-Tyrosine Kinases - metabolism
/ Receptors, Fibroblast Growth Factor - genetics
/ Receptors, Fibroblast Growth Factor - metabolism
/ Receptors, Notch - metabolism
/ Science
