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Predictors of nonresponse to cognitive behavioural therapy or venlafaxine using glucose metabolism in major depressive disorder
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Predictors of nonresponse to cognitive behavioural therapy or venlafaxine using glucose metabolism in major depressive disorder
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Journal Article
Predictors of nonresponse to cognitive behavioural therapy or venlafaxine using glucose metabolism in major depressive disorder
2009
Overview
Background Longitudinal neuroimaging investigations of antidepressant treatment offer the opportunity to identify potential baseline biomarkers associated with poor outcome. Methods To explore the neural correlates of nonresponse to cognitive behavioural therapy (CBT) or venlafaxine (VEN), we compared pretreatment (18)F-fluoro-2-deoxy-D-glucose positron emission tomography scans of participants with major depressive disorder responding to either 16 weeks of CBT ( n = 7) or VEN treatment ( n = 9) with treatment nonresponders ( n = 8). Results Nonresponders to CBT or VEN, in contrast to responders, exhibited pretreatment hypermetabolism at the interface of the pregenual and subgenual cingulate cortices. Limitations Limitations of our study include the small sample sizes and the absence of both arterial sampling to determine absolute glucose metabolism and high-resolution structural magnetic resonance imaging coregistration for region-of-interest analyses. Conclusion Our current findings are consistent with those reported in previous studies of relative hyperactivity in the ventral anterior cingulate cortex in treatment-resistant populations.
Publisher
Canadian Medical Association,NRC Research Press,CMA Impact Inc,Cooperative Education Association
Subject
/ Adult and adolescent clinical studies
/ Antidepressive Agents, Second-Generation - therapeutic use
/ Biological and medical sciences
/ Cyclohexanols - therapeutic use
/ Depressive Disorder, Major - diagnostic imaging
/ Depressive Disorder, Major - drug therapy
/ Depressive Disorder, Major - therapy
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Glucose
/ Gyrus Cinguli - diagnostic imaging
/ Humans
/ Male
/ Methods
/ Positron-Emission Tomography
/ Psychology. Psychoanalysis. Psychiatry
