Asset Details
Do you wish to reserve the book?
The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells
Do you wish to request the book?
The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells
2004
Overview
The human polyomavirus, JCV, causes the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised patients. We found that the serotonergic receptor$5HT_{2A}R$could act as the cellular receptor for JCV on human glial cells. The 5HT2Areceptor antagonists inhibited JCV infection, and monoclonal antibodies directed at 5HT2Areceptors blocked infection of glial cells by JCV, but not by SV40. Transfection of 5HT2Areceptor-negative HeLa cells with a 5HT2Areceptor rescued virus infection, and this infection was blocked by antibody to the 5HT2Areceptor. A tagged 5HT2Areceptor colocalized with labeled JCV in an endosomal compartment following internalization. Serotonin receptor antagonists may thus be useful in the treatment of progressive multifocal leukoencephalopathy.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ Cells
/ Dopamine Agonists - pharmacology
/ Dopamine Antagonists - pharmacology
/ Fluorescent Antibody Technique, Indirect
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ JC virus
/ Leukoencephalopathy, Progressive multifocal
/ Patients
/ Progressive multifocal leukoencephalopathy
/ Receptor, Serotonin, 5-HT2A - immunology
/ Receptor, Serotonin, 5-HT2A - physiology
/ Receptors, Dopamine - immunology
/ Receptors, Dopamine - physiology
/ Receptors, Virus - physiology
/ Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
/ Serotonin 5-HT2 Receptor Antagonists
/ Serotonin Antagonists - pharmacology
/ Virology
/ Viruses
