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Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain
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Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain
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Journal Article
Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain
2000
Overview
The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known about the ligands that activate RXR in vivo. Here, we identified a factor in brain tissue from adult mice that activates RXR in cell-based assays. Purification and analysis of the factor by mass spectrometry revealed that it is docosahexaenoic acid (DHA), a long-chain polyunsaturated fatty acid that is highly enriched in the adult mammalian brain. Previous work has shown that DHA is essential for brain maturation, and deficiency of DHA in both rodents and humans leads to impaired spatial learning and other abnormalities. These data suggest that DHA may influence neural function through activation of an RXR signaling pathway.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ Brain
/ Brain - growth & development
/ Cells
/ Chromatography, High Pressure Liquid
/ Docosahexaenoic Acids - isolation & purification
/ Docosahexaenoic Acids - metabolism
/ Docosahexaenoic Acids - pharmacology
/ Fatty Acids, Unsaturated - pharmacology
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Hexanes
/ Humans
/ Ligands
/ Male
/ Mice
/ Molecular and cellular biology
/ Nuclear Receptor Coactivator 1
/ Receptors, Retinoic Acid - genetics
/ Receptors, Retinoic Acid - metabolism
/ Recombinant Fusion Proteins - metabolism
/ Rodents
/ Spectrometry, Mass, Electrospray Ionization
/ Tissues
/ Transcription Factors - genetics
