Asset Details
Do you wish to reserve the book?
208 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) With Complex Karyotype, Clinic-Pathological Study and Risk for Richter Transformation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
208 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) With Complex Karyotype, Clinic-Pathological Study and Risk for Richter Transformation
Do you wish to request the book?
208 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) With Complex Karyotype, Clinic-Pathological Study and Risk for Richter Transformation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
208 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) With Complex Karyotype, Clinic-Pathological Study and Risk for Richter Transformation
2018
Overview
Abstract
Introduction
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a lymphoid neoplasm of with heterogeneous cytogenetic and molecular abnormalities that are used for prognostication. We aimed to do a clinic-pathological study of CLL/SLL with complex karyotype (≥3 abnormalities) and assess risk of Richter transformation.
Methods
We identified 333 patients with CLL/SLL having complex karyotype at a single institution from January 1969 to December 31, 2015. Clinicopathological parameters were extracted from institutional databases. Logistic regression (SAS 9.4) was applied to test association between parameters and transformation.
Results
Median age was 64 years. Patients included 250 men (75.01%) and 83 women (83%). Laboratory parameters were as follows (median [range]): Hb 11.1 (9.6–12.7) g/dL, WBC 20.6 (7.2–70.9) K/uL, platelets 100 (50–160) K/uL, absolute lymphocyte count 14.96 (3.93–61.11) K/uL, LDH 698 (547–939) IU/L, B2 microglobulin 4.7 (3.2–6.6). Splenomegaly was present in 97 (29.13%) patients, bulky lymphadenopathy in 20 (6.01%). In patients that had results available, CLL cells were positive for ZAP70 in 71% and CD38 in 182 (64.76%) patients. VH mutation was present in 42 (14%). Cytogenetic abnormalities were as follows: -17 in 20 (5.70%), trisomy 12 in 56 (16.82%). A total of 39 patients developed Richter transformation; of these 24 (61.54%) were men and 15(38.46%) women, and median age at time of transformation was 59.5 years. Of 31 patients with survival data, median survival time for Richter transformation was 6.91 years as compared to 7.9 years for 147 subjects without. Only Hb was associated with increased risk of developing Richter transformation.
Conclusion
CLL/SLL with complex karyotype is a heterogeneous disease at the genetic level. Only Hb was associated with risk for Richter transformation.
Publisher
Oxford University Press
Subject
