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Unusual phototransduction via cross-motif signaling from G q to adenylyl cyclase in intrinsically photosensitive retinalganglion cells
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Unusual phototransduction via cross-motif signaling from G q to adenylyl cyclase in intrinsically photosensitive retinalganglion cells
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Unusual phototransduction via cross-motif signaling from G q to adenylyl cyclase in intrinsically photosensitive retinalganglion cells
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Journal Article
Unusual phototransduction via cross-motif signaling from G q to adenylyl cyclase in intrinsically photosensitive retinalganglion cells
2023
Overview
Nonimage-forming vision in mammals is mediated primarily by melanopsin (OPN4)-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs). In mouse M1-ipRGCs, melanopsin predominantly activates, via Gα q,11,14 , phospholipase C-β4 to open transient receptor 6 (TRPC6) and TRPC7 channels. In M2- and M4-ipRGCs, however, a prominent phototransduction mechanism involves the opening of hyperpolarization- and cyclic nucleotide-gated channels via cyclic nucleotide, although the upstream steps remain uncertain. We report here experiments, primarily on M4-ipRGCs, with photo-uncaging of cyclic nucleotides and virally expressed CNGA2 channels to conclude that the second messenger is cyclic adenosine monophosphate (cAMP) – very surprising considering that cyclic guanosine monophosphate (cGMP) is used in almost all cyclic nucleotide-mediated phototransduction mechanisms across the animal kingdom. We further found that the upstream G protein is likewise G q , which via its Gβγ subunits directly activates adenylyl cyclase (AC). Our findings are a demonstration in a native cell of a cross-motif GPCR signaling pathway from G q directly to AC with a specific function.
