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BeQu IK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms
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BeQu IK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms
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Journal Article
BeQu IK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms
2020
Overview
In medical settings, they are associated with chronic infections of tissues and organs (e.g. cystic fibrosis and wounds) or implanted medical devices (e.g. catheters, endotracheal tubes, tissue fillers), where the biofilms effectively hide bacteria from the host immune system and render them up to 1000‐fold less susceptible to antibiotics than in their planktonic state (Gilbert et al., ). [...]the engineered E. coli cells were able to kill both planktonic and biofilm‐residing cells. Nbs against chemical targets have been selected before (Kim et al., ; Bever et al., ). [...]they are capable of binding to small molecules.
