Asset Details
Do you wish to reserve the book?
Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection
Do you wish to request the book?
Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection
2017
Overview
γδ T cells are generally understood to be innate lymphocytes. Prinz and colleagues show that human γδ T cells reconstituted after bone-marrow transplantation have a distinct repertoire that can be shaped by infection with cytomegalovirus, which suggests features of adaptive immunity.
To investigate how the human γδ T cell pool is shaped during ontogeny and how it is regenerated after transplantation of hematopoietic stem cells (HSCs), we applied an RNA-based next-generation sequencing approach to monitor the dynamics of the repertoires of γδ T cell antigen receptors (TCRs) before and after transplantation in a prospective cohort study. We found that repertoires of rearranged genes encoding γδ TCRs (
TRG
and
TRD
) in the peripheral blood of healthy adults were stable over time. Although a large fraction of human
TRG
repertoires consisted of public sequences, the
TRD
repertoires were private. In patients undergoing HSC transplantation, γδ T cells were quickly reconstituted; however, they had profoundly altered TCR repertoires. Notably, the clonal proliferation of individual virus-reactive γδ TCR sequences in patients with reactivation of cytomegalovirus revealed strong evidence for adaptive anti-viral γδ T cell immune responses.
Publisher
Nature Publishing Group US
Subject
/ Clonal Evolution - immunology
/ Cytomegalovirus Infections - genetics
/ Cytomegalovirus Infections - immunology
/ Cytomegalovirus Infections - virology
/ Gene Rearrangement, T-Lymphocyte
/ Hematopoietic Stem Cell Transplantation
/ Humans
/ Lymphocyte Activation - genetics
/ Lymphocyte Activation - immunology
/ Receptors, Antigen, T-Cell, gamma-delta - genetics
/ Receptors, Antigen, T-Cell, gamma-delta - metabolism
/ T-Lymphocyte Subsets - immunology
