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Two distinct populations of Bovine IL-17+ T-cells can be induced and WC1+IL-17+γδ T-cells are effective killers of protozoan parasites
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Two distinct populations of Bovine IL-17+ T-cells can be induced and WC1+IL-17+γδ T-cells are effective killers of protozoan parasites
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Journal Article
Two distinct populations of Bovine IL-17+ T-cells can be induced and WC1+IL-17+γδ T-cells are effective killers of protozoan parasites
2014
Overview
IL-17 has emerged as a key player in the immune system, exhibiting roles in protection from infectious diseases and promoting inflammation in autoimmunity. Initially thought to be CD4 T-cell-derived, the sources of IL-17 are now known to be varied and belong to both the innate and adaptive arms of the immune system. Mechanisms for inducing IL-17 production in lymphoid cells are thought to rely on appropriate antigenic stimulation in the context of TGF-β1, IL-6 and/or IL-1β. Using culture protocols adapted from human studies, we have effectively induced both bovine CD4
+
and WC1
+
γδ T-cells to produce IL-17 termed Th17 and γδ17 cells, respectively. The negative regulatory effect of IFN-γ on mouse and human IL-17 production can be extended to the bovine model, as addition of IFN-γ decreases IL-17 production in both cell types. Furthermore we show that infection with the protozoan
Neospora caninum
will induce fibroblasts to secrete pro-IL-17 factors thereby inducing a γδ17 phenotype that preferentially kills infected target cells. Our study identifies two T-cell sources of IL-17 and is the first to demonstrate a protective effect of IL-17
+
T-cells in ruminants. Our findings offer further opportunities for future adjuvants or vaccines which could benefit from inducing these responses.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 13/21
/ 14/63
/ 38/77
/ 631/250
/ 631/326
/ 64
/ 82
/ Animals
/ Cattle
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - metabolism
/ CD4-Positive T-Lymphocytes - parasitology
/ Cytotoxicity, Immunologic - immunology
/ Host-Parasite Interactions - immunology
/ Humanities and Social Sciences
/ Interferon-gamma - immunology
/ Interferon-gamma - pharmacology
/ Interleukin-6 - pharmacology
/ Membrane Glycoproteins - immunology
/ Membrane Glycoproteins - metabolism
/ Receptors, Antigen, T-Cell, gamma-delta - immunology
/ Receptors, Antigen, T-Cell, gamma-delta - metabolism
/ Science
/ Transforming Growth Factor beta1 - immunology
