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Plasma Membrane Calcium Pump Activity in Rat Pancreatic Islets: An Accurate Method to Measure its Calcium-Dependent Modulation

by Grover, A.K. , Rossi, Juan Pablo F.C. , Echarte, M.M. , Alzugaray, M. E. , Villamil, A. M. , Gagliardino, J. J. , García, M.E. , Pande, J. , Borelli, M. I.

in Animals / Calcium / Calcium - physiology / Cell Membrane - drug effects / Cell Membrane - enzymology / Glucose - pharmacology / In Vitro Techniques / Ion Channel Gating / Islets of Langerhans - drug effects / Islets of Langerhans - enzymology / Isoenzymes - physiology / Male / Pancreas / Phosphorylation / Plasma Membrane Calcium-Transporting ATPases - physiology / Rats / Rats, Wistar / Rodents

2006

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Plasma Membrane Calcium Pump Activity in Rat Pancreatic Islets: An Accurate Method to Measure its Calcium-Dependent Modulation

by Grover, A.K. , Rossi, Juan Pablo F.C. , Echarte, M.M. , Alzugaray, M. E. , Villamil, A. M. , Gagliardino, J. J. , García, M.E. , Pande, J. , Borelli, M. I.

2006

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Plasma Membrane Calcium Pump Activity in Rat Pancreatic Islets: An Accurate Method to Measure its Calcium-Dependent Modulation

by Grover, A.K. , Rossi, Juan Pablo F.C. , Echarte, M.M. , Alzugaray, M. E. , Villamil, A. M. , Gagliardino, J. J. , García, M.E. , Pande, J. , Borelli, M. I.

2006

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Journal Article

Plasma Membrane Calcium Pump Activity in Rat Pancreatic Islets: An Accurate Method to Measure its Calcium-Dependent Modulation

Grover, A.K.,

Rossi, Juan Pablo F.C.,

Echarte, M.M.,

Alzugaray, M. E.,

Villamil, A. M.,

Gagliardino, J. J.,

García, M.E.,

Pande, J.,

Borelli, M. I.

2006

Overview

The aim of this study was to quantify the glucose modulation of the plasma membrane calcium pump (PMCA) function in rat pancreatic islets. Ca2+-ATPase activity and levels of phosphorylated PMCA intermediates both transiently declined to a minimum in response to stimulation by glucose. Strictly dependent on Ca2+ concentration, this inhibitory effect was fully expressed at physiological concentrations of the cation (less than 0.5 muM), then progressively diminished at higher concentrations. These results, together with those previously reported on the effects of insulin secretagogues and blockers on the activity, expression and cellular distribution of the PMCA, support the concept that the PMCA plays a key role in the regulation of Ca2+ signaling and insulin secretion in pancreatic islets.

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Publisher

Springer Nature B.V

Subject

Animals

/ Calcium

/ Calcium - physiology

/ Cell Membrane - drug effects

/ Cell Membrane - enzymology

/ Glucose - pharmacology

/ In Vitro Techniques