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Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions
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Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions
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Journal Article
Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions
1995
Overview
The elucidation of molecular alterations that occur during human breast cancer progression may contribute to the development of preventative strategies. Using
in situ
hybridizations on a cohort of 94 biopsy lesions, quantitatively increased cyclin D mRNA expression levels were observed in only 18% of benign lesions, which confer no or slightly increased breast cancer risk, and 18% of premalignant atypical ductal hyperplasias, which confer a four to fivefold increase in breast cancer risk. The transition to carcinoma was accompanied by frequent cyclin D mRNA overexpression in 76% of low-grade ductal carcinomas
in situ
, 87% of higher grade comedo ductal carcinomas
in situ
and 83% of infiltrating ductal breast carcinomas. The data identify a molecular event that may separate benign and premalignant human breast lesions from any form of breast carcinoma.
Publisher
Nature Publishing Group US
Subject
/ Breast Neoplasms - metabolism
/ Breast Neoplasms - pathology
/ Carcinoma, Ductal, Breast - metabolism
/ Carcinoma, Ductal, Breast - pathology
/ Carcinoma, Intraductal, Noninfiltrating - metabolism
/ Carcinoma, Intraductal, Noninfiltrating - pathology
/ Female
/ Fibrocystic Breast Disease - metabolism
/ Fibrocystic Breast Disease - pathology
/ Humans
/ Oncogene Proteins - genetics
