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Mapping drug resistance variants in cancer, one base at a time
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Journal Article
Mapping drug resistance variants in cancer, one base at a time
2024
Overview
DNA variants arising in the genome of cancer cells are a major cause of therapy failure, but for most variants, their effects on drug response are unknown. Base-editing screens provide a systematic approach to uncover the functions of cancer variants at scale, which might help to inform the use of precision cancer therapies.
Publisher
Nature Publishing Group US
