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An Overview on the N-Heterocyclic Carbene-Catalyzed Aza-Benzoin Condensation Reaction
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An Overview on the N-Heterocyclic Carbene-Catalyzed Aza-Benzoin Condensation Reaction
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Journal Article
An Overview on the N-Heterocyclic Carbene-Catalyzed Aza-Benzoin Condensation Reaction
2018
Overview
The N-heterocyclic carbene(NHCs)-catalyzed aza-benzoin condensation reaction is an efficient, single step strategy which employs easily available substrates, such as aldehydes and imines, to provide α-amino ketones. The multifunctionality and high reactivity of α-amino ketones makes these structures attractive for medicinal chemistry and as precursors of a variety of amine derivatives. The different electrophilic characteristics of aldehydes and imines ensure a high regioselective reaction. Enantiomerically-enriched α-amino ketones have been synthesized through stereoselective couplings promoted by chiral N-heterocyclic carbenes. One-pot domino procedures, including an aza-benzoin step, allow valuable complex molecules to be accessed.
